106854-77-7 | 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene

CAS:106854-77-7 | 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene ,Description

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene (BTFEB) is a highly versatile compound with a wide range of applications in the chemical, biological and pharmaceutical sciences. BTFEB is a halogenated aromatic compound with a bromine atom attached to the 4-position of a benzene ring and a trifluoroethoxy group attached to the 1-position. It is a colorless liquid at room temperature and has a boiling point of about 95°C. It is soluble in water, methanol, ethanol, and other organic solvents.
 

Scientific Research Applications

• Study of Regioselectivity in Metalation of Halobenzotrifluorides: This compound is used in examining the regioselectivity in metalation processes involving halobenzotrifluorides (Mongin, Desponds, & Schlosser, 1996).
• Ring Halogenations of Polyalkylbenzenes: It is utilized in ring halogenation reactions of polyalkylbenzenes, aiding in the preparation of compounds like 2-bromo-4-iodo-1,3,5-trimethylbenzene with high yield (Bovonsombat & Mcnelis, 1993).
• Synthesis of Graphene Nanoribbons: This compound serves as a precursor in the bottom-up synthesis of planar one-dimensional graphene nanoribbons with controlled edge morphology and narrow widths (Patil et al., 2012).
• Production of Trifluoromethoxy Naphthalenes and Naphthols: It is used in chemical reactions to produce 1- and 2-(trifluoromethoxy)naphthalenes, trifluoromethoxy-1-naphthols, and vic-dibromides (Schlosser & Castagnetti, 2001).
• Synthesis of Conjugated Dienes with CF3 Group: It facilitates the addition of 1-bromo-1-chloro-2,2,2-trifluoroethane to allylbenzenes, leading to the synthesis of conjugated dienes with a terminal CF3 group (Ignatowska & Dmowski, 2006).
• Organometallic Synthesis: 1-Bromo-3,5-bis(trifluoromethyl)benzene, a related compound, is a starting material for various synthetically useful reactions in organometallic synthesis (Porwisiak & Schlosser, 1996).
• Synthesis of Chiral 1-Halo-1-Bromo Compounds: It may be a valuable synthetic intermediate in organic synthesis, particularly for the synthesis of chiral 1-halo-1-bromo compounds (González et al., 2003) .

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