107496-54-8 | 3,3-Difluorocyclobutanecarboxylic acid

CAS:107496-54-8 | 3,3-Difluorocyclobutanecarboxylic acid ,Description

3,3-Difluorocyclobutanecarboxylic acid (DFCA) is an organic compound with the molecular formula of C4H4F2O2. It is a colorless liquid that is soluble in organic solvents and has a low melting point. DFCA is a versatile compound that is used in a variety of applications, such as pharmaceuticals, agrochemicals, and other industrial processes. Its unique structure and properties make it an ideal candidate for synthesizing a wide range of compounds.
 

Scientific Research Applications

Synthesis of Building Blocks

3,3-Difluorocyclobutanecarboxylic acid is valuable in the synthesis of various building blocks. For instance, it serves as a common synthetic intermediate in creating carboxylic acid, amines, alcohols, azides, and trifluoroborate ketones, highlighting its versatility in chemical synthesis (Ryabukhin et al., 2018).

Fluorinated Amino Acid Analogues

The compound is used in synthesizing fluorinated analogues of amino acids. For example, 1-amino-3,3-difluorocyclobutanecarboxylic acid, a new fluorinated analogue, was synthesized from acetone, indicating its potential in creating novel bioactive compounds (Mykhailiuk et al., 2010).

PET Imaging Applications

The compound's derivatives, such as 1-amino-3-fluorocyclobutane-1-carboxylic acid, have been explored for nuclear medicine imaging, particularly in tumor localization using positron emission tomography (PET) (Shoup et al., 1999).

Development of Radiotracers

It has also been instrumental in the development of radiotracers like anti-1-amino-3-[18F]fluoromethyl-cyclobutane-1-carboxylic acid (FMACBC), which shows promise for imaging brain tumors in rodent models (Martarello et al., 2002).

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