107873-03-0 | 2,2-Difluorocyclopropanecarboxylic acid

CAS:107873-03-0 | 2,2-Difluorocyclopropanecarboxylic acid ,Description

2,2-Difluorocyclopropanecarboxylic acid (DFCA) is an organic compound with a molecular formula of C3H3F2O2. It is a colorless, water-soluble liquid with a strong odor. DFCA is used in a variety of scientific research applications, and its biochemical and physiological effects are being studied for potential therapeutic applications. This article will discuss the synthesis method, scientific research applications, mechanism of action, biochemical and physiological effects, advantages and limitations for lab experiments, and future directions for DFCA research. 
 

Scientific Research Applications

• Synthesis of Analogous Compounds for Plant Growth Regulation: A study by Kimpe, Sulmon, and Brunet (1990) in the Journal of Organic Chemistry outlines a novel method for synthesizing 2,2-dialkyl-1-aminocyclopropanecarboxylic acids, showing potential as plant growth regulators (Kimpe, Sulmon, & Brunet, 1990).
• Pharmaceutical and Pesticide Production: A paper by Li Gong (2007) in Liaoning Chemical Industry discusses the synthesis and resolution of 2,2-dimethylcyclopropane carboxylic acid, emphasizing the importance of chiral products in pharmaceutical and pesticide production (Gong, 2007).
• Drug Discovery Tool: Thomson et al. (2018) in Chemical Communications highlight that the partially fluorinated cyclopropane motif has a similar lipophilicity to -CF3, offering a promising tool in drug discovery (Thomson et al., 2018).
• One-Pot Amidation Reaction for Carboxylic Acids: Wang et al. (2021) in Organic Letters describe how CpFluor effectively deoxyfluorinates carboxylic acids to acyl fluorides and amides, providing a one-pot amidation reaction for carboxylic acids (Wang et al., 2021).
• Inhibition of Specific Enzymes: A study by Liu et al. (2015) in Organic Letters reveals that 2,2-difluorocyclopropanecarboxylic acid derivatives act as slow-dissociating inhibitors of specific enzymes (Liu et al., 2015).
• Efficient Synthesis of Enantiomers: Kirihara et al. (2003) in Tetrahedron-Asymmetry present a lipase-catalyzed desymmetrization method for synthesizing (R)- and (S)-1-amino-2,2-difluorocyclopropanecarboxylic acid, achieving distinct enantiomers (Kirihara et al., 2003).
• Herbicidal and Fungicidal Activity: Tian et al. (2009) in Chinese Chemical Letters report that certain N-(substituted) cyclopropanecarboxyl-N′-pyridin-2-yl thioureas exhibit excellent herbicidal and fungicidal activities (Tian et al., 2009).
• Analgesic-Antiinflammatory Applications: A study by Hannah et al. (1978) in the Journal of Medicinal Chemistry discusses the development of diflunisal, a more effective and safer analgesic-antiinflammatory agent than aspirin, derived from similar chemical structures (Hannah et al., 1978).

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