1082040-43-4 | 6-Fluoro-1H-indole-4-carboxylic acid methyl ester

CAS:1082040-43-4 | 6-Fluoro-1H-indole-4-carboxylic acid methyl ester,Description

Methyl 6-fluoro-1H-indole-4-carboxylate (MFC) is a synthetic molecule that has been studied extensively for its potential applications in the fields of science and medicine. MFC is a highly versatile compound that has been used in a variety of scientific research applications, including drug development and medical diagnostics. It has also been used to study the biochemical and physiological effects of various compounds on the body. This article will discuss the synthesis method of MFC, its scientific research applications, its mechanism of action, its biochemical and physiological effects, its advantages and limitations for lab experiments, and its future directions. 
 

Scientific Research Applications

1. As a Key Intermediate in HIV Treatment Development

Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate, closely related to Methyl 6-fluoro-1H-indole-4-carboxylate, has been used in the synthesis of phosphoindole inhibitors targeting HIV non-nucleoside reverse transcriptase. This synthesis approach offers safer alternatives to potentially hazardous methodologies, and the compounds developed show promise in the treatment of HIV (Mayes et al., 2010).

2. As a Fluorescent and Infrared Probe

Methyl indole-4-carboxylate, a variant of Methyl 6-fluoro-1H-indole-4-carboxylate, demonstrates potential as a fluorescent probe for protein local structure and dynamics due to its emission around 450 nm with a fairly long fluorescence lifetime. Its sensitivity to local hydration environments makes it a useful infrared probe (Liu et al., 2020).

3. In Antimicrobial and Anticancer Research

Compounds like 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters, which share a core structure with Methyl 6-fluoro-1H-indole-4-carboxylate, have demonstrated significant antimicrobial and anticancer properties. These compounds have shown potency comparable to standard drugs against specific bacteria and cancer cell lines (Sharma et al., 2012).

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