1108745-30-7 | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine

CAS:1108745-30-7 | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine,Description

Molecular Structure Analysis

The molecular structure of the parent compounds, 3,5-Difluorobenzyl alcohol and 3,5-Difluorobenzyl bromide, have molecular weights of 144.119 Da and 207.015 Da respectively. The molecular formula of “5-(3,5-Difluorobenzyl)-1H-indazol-3-amine” is C14H11F2N3, with a molecular weight of 259.26.

Physical And Chemical Properties Analysis

The parent compounds, 3,5-Difluorobenzyl alcohol and 3,5-Difluorobenzyl bromide, have densities of 1.3±0.1 g/cm3 and 1.6±0.1 g/cm3 respectively. They have boiling points of 182.0±25.0 °C and 205.1±0.0 °C respectively at 760 mmHg.

Scientific Research Applications

Synthesis and Structure

• The compound 5-(3,5-Difluorobenzyl)-1H-indazol-3-amine is involved in the synthesis of various chemical structures. For instance, a related compound, 4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)-N-(2-hydroxy-3,5-diiodinebenzyl)thiazol-2-amine, was synthesized and its crystal structure was determined, showcasing its potential in forming complex structures with biological activity (叶姣 et al., 2015) .

Catalysis and Chemical Reactions

• Indazole compounds, closely related to 5-(3,5-Difluorobenzyl)-1H-indazol-3-amine, are frequently used in palladium-catalyzed intramolecular amination reactions. These reactions are crucial for the synthesis of various indazole derivatives, indicating the compound's role in facilitating chemical transformations (Song & Yee, 2001).

Antitumor Activity

• Related indazole derivatives have shown promise in antitumor activities. This suggests that compounds like 5-(3,5-Difluorobenzyl)-1H-indazol-3-amine could potentially be explored for their effects in cancer research and treatment (Hao et al., 2017).

Anticancer Properties

• In the realm of anticancer research, 6-aminoindazole derivatives, similar to 5-(3,5-Difluorobenzyl)-1H-indazol-3-amine, have been synthesized and evaluated for antiproliferative activity in various cancer cell lines. This points to the potential use of such compounds in developing new anticancer agents (Ngo Xuan Hoang et al., 2022).

Safety And Hazards

3,5-Difluorobenzyl Chloride, a related compound, is considered hazardous. It causes skin irritation, serious eye irritation, and may cause respiratory irritation. It is recommended to avoid breathing dust/fume/gas/mist/vapors/spray and to use only outdoors or in a well-ventilated area.

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