112738-67-7 | 1-(TRIFLUOROMETHYL)CYCLOPROPANAMINE

CAS:112738-67-7 | 1-(TRIFLUOROMETHYL)CYCLOPROPANAMINE,Description

1-(Trifluoromethyl)cyclopropanamine hydrochloride is a chemical compound with the molecular formula CHClFN. It has an average mass of 161.553 Da and a monoisotopic mass of 161.021912 Da. It is a solid substance that is stored in an inert atmosphere at temperatures between 2-8°C.

Molecular Structure Analysis

The molecular structure of 1-(Trifluoromethyl)cyclopropanamine hydrochloride consists of a cyclopropane ring with a trifluoromethyl group and an amine group attached. The presence of the trifluoromethyl group can significantly influence the compound’s physical and chemical properties due to the high electronegativity of fluorine.

Physical And Chemical Properties Analysis

1-(Trifluoromethyl)cyclopropanamine hydrochloride is a solid substance. It is stored in an inert atmosphere at temperatures between 2-8°C. More specific physical and chemical properties such as density, boiling point, vapor pressure, enthalpy of vaporization, flash point, index of refraction, molar refractivity, and others are not provided in the search results.

Scientific Research Applications

• Synthesis Techniques :
  • A method for synthesizing trans-2-(Trifluoromethyl)cyclopropanamine, a compound closely related to 1-(Trifluoromethyl)cyclopropanamine hydrochloride, was developed using sulfur tetrafluoride to transform the carboxy group into the trifluoromethyl group (Bezdudny et al., 2011).
  • An enantioselective cobalt-catalyzed process has been reported for producing trifluoromethyl-substituted cyclopropanes (Morandi et al., 2011).
  • A Corey-Chaykovsky reaction approach for synthesizing cis-configured trifluoromethyl cyclopropanes offers excellent yields and good diastereoselectivities (Hock et al., 2017).
• Pharmaceutical Applications :
  • Cyclopropanamine compounds, including those with a trifluoromethyl group, have potential applications in the treatment of CNS disorders, like schizophrenia and Alzheimer's disease, by inhibiting Lysine-specific demethylase-1 (LSD1) (Blass, 2016).
• Building Blocks for Drug Discovery :
  • Trifluoromethyl-substituted cyclopropanes are important as building blocks in pharmaceutical and agrochemical industries. Efficient strategies using myoglobin-catalyzed olefin cyclopropanation reactions have been developed for their asymmetric synthesis (Tinoco et al., 2017).
• Other Chemical Synthesis Applications :
  • The synthesis of distally fluorinated ketones has been achieved using tertiary cyclopropanols, derived from carboxylic esters, with sodium triflinate acting as a fluoroalkylating agent (Konik et al., 2017).
  • A diastereoselective synthesis method for cyclopropanes bearing trifluoromethyl-substituted all-carbon quaternary centers has been described, offering a new approach for the synthesis of these compounds (Chen et al., 2019).

Safety And Hazards

The safety information for 1-(Trifluoromethyl)cyclopropanamine hydrochloride indicates that it has the GHS07 pictogram. The hazard statements include H302, H315, H319, and H335, which suggest that the compound may be harmful if swallowed, may cause skin irritation, may cause serious eye irritation, and may cause respiratory irritation. The precautionary statements include P261, P305+P351+P338, which suggest avoiding breathing dust/fume/gas/mist/vapors/spray, and if in eyes, rinse cautiously with water for several minutes.

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