113512-71-3 | 5-AMINO-2,4-DIFLUOROPHENOL

CAS:113512-71-3 | 5-AMINO-2,4-DIFLUOROPHENOL,Description

5-Amino-2,4-difluorophenol is a research chemical with the CAS Number: 113512-71-3. It has a molecular weight of 145.11and is commonly used for organic synthesis and other chemical processes.

Molecular Structure Analysis

The molecular structure of 5-Amino-2,4-difluorophenol contains a total of 15 bonds; 10 non-H bonds, 6 multiple bonds, 6 aromatic bonds, 1 six-membered ring, 1 primary amine (aromatic), and 1 aromatic hydroxyl.

Physical And Chemical Properties Analysis

5-Amino-2,4-difluorophenol is a solid at room temperature. It has a boiling point of 246.5°C at 760 mmHg. The compound should be stored in a dark place, in an inert atmosphere, at room temperature.

Scientific Research Applications

Applications in Medicinal Chemistry

• Analgesic and Anti-inflammatory Properties : 5-(2,4-Difluorophenyl)salicylic acid, a compound related to 5-Amino-2,4-difluorophenol, has been identified as a potent analgesic and anti-inflammatory agent, more effective than aspirin in both efficacy and safety (Hannah et al., 1978).

Biochemical Research

• Amino Acid Analysis : A bifunctional reagent derived from 1,5-difluoro-2,4-dinitrobenzene, closely related to 5-Amino-2,4-difluorophenol, has been used for distinguishing and quantifying L- and D-amino acids in mixtures (Marfey, 1984).

Organic Synthesis

• Synthesis of Cyclopentadienols : 1-Amino-2,3-diphenylcyclopropenium ions, which are structurally related to 5-Amino-2,4-difluorophenol, have been utilized in the synthesis of cyclopentadienols (Yoshida et al., 1988).

Drug Design

• Bioisostere for Carboxylic Acids : The 2,6-difluorophenol moiety, closely related to 5-Amino-2,4-difluorophenol, has been tested as a lipophilic bioisostere of carboxylic acids in drug candidates (Qiu et al., 1999).

Chemistry of Organometallic Compounds

• Functionalization of Difluorophenols : The regioexhaustive functionalization of various difluorophenols, including 2,4-difluorophenol, has been achieved, demonstrating the potential of the organometallic approach in diversity-oriented synthesis (Marzi et al., 2004).

Material Science

• Dye Industry Applications : Derivatives of 2,4-difluorophenol have been identified in internet-purchased products and are relevant to the dye industry (Stańczuk et al., 2013) .
• Optical and Dielectric Properties : The internal linkage groups of fluorinated diamine, including compounds related to 5-Amino-2,4-difluorophenol, affect the optical and dielectric properties of polyimide thin films (Jang et al., 2007).

Safety And Hazards

The compound is labeled with the signal word “Warning” and has hazard statements H302, H315, H319, and H335, indicating that it is harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation. Precautionary measures include avoiding breathing dust/fume/gas/mist/vapors/spray and rinsing cautiously with water for several minutes in case of contact with eyes.

More Information