114435-86-8 | Fluoromethyl 4-methylbenzenesulfonate

CAS:114435-86-8 | Fluoromethyl 4-methylbenzenesulfonate ,Description

Fluoromethyl 4-methylbenzenesulfonate (FMBS) is an organic fluorinated compound with a wide range of applications in scientific research. It is a sulfonate ester of 4-methylbenzene, which is a derivative of benzene with a methyl group attached to one of the carbon atoms. FMBS is a colorless liquid at room temperature, with a boiling point of 146°C and a melting point of -46°C. It is soluble in a variety of organic solvents, including alcohols, esters, and ethers. FMBS has a relatively low toxicity, making it an attractive choice for laboratory use. 
 

Scientific Research Applications

1. Molecular Structure Studies

• Study of 4-Methylbenzenesulfonate Anion: An investigation into the molecular structure of the 4-methylbenzenesulfonate anion, which is related to Fluoromethyl 4-methylbenzenesulfonate, was conducted. The geometry of the anion was optimized and analyzed using ab initio quantum chemical methods. This research provided valuable insights for understanding the internal vibrational modes of the anion in 4-methylbenzenesulfonate salts (Ristova, Pejov, Žugić, & Šoptrajanov, 1999).

2. Bioconjugation and Biomedical Applications

• Activation of Hydroxyl Groups in Polymers: A study on 4-fluorobenzenesulfonyl chloride, closely related to Fluoromethyl 4-methylbenzenesulfonate, demonstrated its effectiveness in activating hydroxyl groups in polymers for the covalent attachment of biological substances. This has potential therapeutic applications, including bioselective separation of human lymphocyte subsets and tumor cells (Chang, Gee, Smith, & Lake, 1992).

3. Nonlinear Optical Applications

• Nonlinear Optical Ionic Quinolinium Crystals: Research on nonlinear optical ionic quinolinium crystals with aromatic anions, including those similar to 4-methylbenzenesulfonate, highlighted their use in optimizing nonlinear optical responses. This study is significant for the development of materials with enhanced optical properties (Lee et al., 2018) .

4. Organic Synthesis and Chemical Applications

• Synthesis of Alkylidenecyclopropanes: A practical and economical method for synthesizing 1-vinylcyclopropyl 4-methylbenzenesulfonate, a compound related to Fluoromethyl 4-methylbenzenesulfonate, was developed. This compound is essential for creating various alicyclic systems (Ojo, Inglesby, Negru, & Evans, 2014).

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