115144-40-6 | 3,4-Difluoroanisole

CAS:115144-40-6 | 3,4-Difluoroanisole,Description

3,4-Difluoroanisole is a chemical compound studied for its molecular structure and conformational properties. Research has utilized techniques like gas electron diffraction and quantum chemical methods to understand its properties.

Synthesis Analysis

Although specific synthesis methods for 3,4-Difluoroanisole are not detailed in the provided papers, the synthesis of related fluorinated compounds often involves complex reactions. For instance, reactions of difluorodienes derived from dibromo difluoro compounds indicate the intricate processes involved in synthesizing such fluorinated organic compounds (Elsheimer et al., 1996).

Molecular Structure Analysis

Studies have shown that 3,4-Difluoroanisole exists in different conformations. Gas electron diffraction and quantum chemical calculations reveal planar conformers, which are crucial in understanding the compound's molecular behavior (Giricheva et al., 2004).

Chemical Reactions and Properties

3,4-Difluoroanisole's reactions, particularly in relation to its rotamers, have been studied. Two-color resonant two-photon mass-analyzed threshold ionization spectroscopy was used to study its vibronic and cation spectra, indicating its reactive properties and energy states (Xu et al., 2012).

Physical Properties Analysis

The physical properties of 3,4-Difluoroanisole, particularly its conformational and molecular structure, have been comprehensively studied through gas-phase electron diffraction and quantum chemical calculations. These studies provide insights into its planar structure and potential energy states (Zarembo et al., 2006).

Chemical Properties Analysis

The chemical properties of 3,4-Difluoroanisole, particularly its reactivity and interaction with other molecules, are highlighted through its spectroscopic properties and theoretical calculations. For example, its interaction with diethyl sodio(phenyl)malonate and anisole under different temperatures reveals its reactive nature (Banks et al., 1990).

Scientific Research Applications

• 3,4-Difluoroanisole is a chemical compound with the molecular formula C7H6F2O . It has a molecular weight of 144.12 and a density of 1.21 . It is also known as 1,2-difluoro-4-methoxybenzene .
• It is a liquid at room temperature.
• One of the applications of a similar compound, 4-Bromo-3,5-difluoroanisole , is in the preparation of difluorophenacyl analogs as inhibitors of cyclin-dependent kinases. It is also used to synthesize aminopyridine N-oxides for selective inhibition of p38 MAP kinase.

Safety And Hazards

3,4-Difluoroanisole is considered hazardous. It is flammable and can cause skin irritation, serious eye irritation, and may cause respiratory irritation. Safety measures include wearing protective gloves, protective clothing, eye protection, and face protection. It should be used only outdoors or in a well-ventilated area.

More Information