115262-01-6 | (Bromodifluoromethyl)trimethylsilane

CAS:115262-01-6 | (Bromodifluoromethyl)trimethylsilane ,Description

(Bromodifluoromethyl)trimethylsilane, or BDMS, is a versatile and useful organosilicon compound with a wide range of applications in chemistry, biochemistry, and materials science. It is a colorless liquid at room temperature and is soluble in organic solvents. BDMS is used as a reagent in the synthesis of various compounds and has the ability to react with a variety of substrates. It is also used as a catalyst in organic synthesis and as a ligand in coordination chemistry.
 

Scientific Research Applications

• Nucleophilic Difluoromethylation: It serves as a source of difluorinated phosphorus ylide under mild conditions. This system has been used effectively for nucleophilic difluoromethylation of ketones and nitro alkenes, particularly due to the Lewis acidic activation of substrates by a silylium species formed upon generation of the phosphorus ylide (Trifonov et al., 2016).
• Deoxygenative Gem-difluoroolefination: It has been compared to other similar compounds for synthesizing gem-difluoroolefins from carbonyl compounds. Though found to be less effective than some alternatives, its reactivity in such reactions provides valuable insights (Wang et al., 2014).
• Iododifluoromethylation of Aldehydes: Utilizing sodium iodide, it has been employed for iododifluoromethylation of aromatic aldehydes. This process involves a selective formation of the CF2I group and demonstrates potential for further chemical transformations (Levin et al., 2015).
• Dithiocarbamate-substituted Gem-difluorinated Silicon Reagent: It is used in the preparation of a gem-difluorinated silicon reagent bearing a pyrrolidine dithiocarbamate substituent, showcasing its role in the development of new chemical reagents (Maslov et al., 2015).
• Functionalized Tetrafluoroethylene Fragments: It's used in preparing a fluorinated silicon reagent with a functionalized tetrafluoroethylene fragment, demonstrating its versatility in the creation of complex fluorinated compounds (Fedorov et al., 2016).
• Structural Studies with Hexamethylphosphoramide (HMPA): The interaction of (bromodifluoromethyl)trimethylsilane with HMPA provides insights into the structural and chemical properties of difluorinated silicon reagents (Supranovich et al., 2021).

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