115761-79-0 | 1-(2,4-Difluorophenyl)piperazine

CAS:115761-79-0 | 1-(2,4-Difluorophenyl)piperazine,Description

Synthesis Analysis

The synthesis of piperazine derivatives, including those similar to 1-(2,4-Difluorophenyl)piperazine, typically involves multi-step processes that may include alkylation, acidulation, reduction of nitro groups, diazotization, substitution, and hydrolysis reactions. The synthesis process aims to achieve high yields and purity of the desired product. For instance, derivatives like 1-(2,3-dichlorophenyl)piperazine have been synthesized with a total yield of approximately 48.2%, demonstrating the efficiency of these synthetic routes (Quan, 2006).

Scientific Research Applications

• Piperazine derivatives, including 1-(2,4-Difluorophenyl)piperazine, have shown potential as therapeutic tools for treating a variety of diseases. These include applications as antipsychotic, antidepressant, and anxiolytic agents (Brito et al., 2018).
• They also exhibit a broad therapeutic potential in other areas such as central nervous system (CNS) disorders, anticancer, cardio-protective, antiviral, anti-tuberculosis, anti-inflammatory, antidiabetic, and imaging applications (Rathi et al., 2016).
• Certain piperazine derivatives have shown cytotoxic properties against prostate cancer cells, indicating their potential as anticancer agents (Bhat et al., 2018).
• The compound has also been investigated for its potential use in forensic science, particularly in detecting new piperazine-type drugs in urine and blood samples of drug addicts (Chang et al., 2017).
• Some studies have focused on the synthesis of 1-(2,3-dichlorophenyl)piperazine from 2,6-dichloro-nitrobenzene and piperazine, demonstrating its structural integrity through IR and 1H-NMR analyses (Quan, 2006).
• In the field of oncology, novel analogues of 1-(2,4-Difluorophenyl)piperazine have shown potential for use as positron emission tomography radiotracers (Abate et al., 2011).
• Some piperazine derivatives have demonstrated promising antifungal activity against various fungal species, suggesting their potential use in antifungal pharmaceuticals (Upadhayaya et al., 2004).
• The novel compound RX-5902, which interacts with p68 RNA helicase, has been shown to inhibit tumor growth and enhance survival in various tumor xenograft models (Lee et al., 2013).

Safety And Hazards

“1-(2,4-Difluorophenyl)piperazine” is considered hazardous and can cause skin irritation, serious eye irritation, and may cause respiratory irritation. It is recommended to avoid breathing its dust/fume/gas/mist/vapors/spray and to use it only outdoors or in a well-ventilated area.

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