1175536-50-1 | (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Mesylate

CAS:1175536-50-1 | (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Mesylate,Description

(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol with methanesulfonate, also known as (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol with methanesulfonate, is a useful research compound. Its molecular formula is C13H17F2N3O5S and its molecular weight is 365.352. The purity is usually 95%.
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Detailed Synthesis Method

Design of the Synthesis Pathway
The synthesis pathway for (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol with methanesulfonate involves the protection of a diol intermediate, followed by a substitution reaction with the 1H-1,2,4-triazole ring, and finally, the deprotection of the diol intermediate with methanesulfonic acid.

Starting Materials
2,4-difluorobenzene, butane-2,3-diol, 1H-1,2,4-triazole, methanesulfonic acid, diol protecting agent (e.g. TBDMS)

Reaction
Step 1: Protect the diol intermediate by reacting it with a diol protecting agent (e.g. TBDMS) in the presence of a catalyst (e.g. DMAP) and a base (e.g. pyridine)., Step 2: React the protected diol intermediate with 1H-1,2,4-triazole in the presence of a coupling agent (e.g. EDC) and a base (e.g. DIPEA) to form the desired product., Step 3: Deprotect the diol intermediate by reacting it with methanesulfonic acid in the presence of a catalyst (e.g. p-toluenesulfonic acid) and a base (e.g. sodium bicarbonate) to obtain the final product as the methanesulfonate salt.

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Uses