117724-63-7 | 2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic Acid

CAS:117724-63-7 | 2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic Acid ,Description

2-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid (MTFTC) is a compound of the thiazole family, which is a heterocyclic sulfur-containing aromatic ring system. It is a white crystalline solid with a molecular weight of 215.2 g/mol and a melting point of 170-175°C. MTFTC is used as a building block for the synthesis of various compounds, and it has a wide range of applications in the fields of chemistry, material science, and pharmaceuticals.
 

Scientific Research Applications

Synthetic Process and Chemical Reactions2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic Acid, utilized as a primary material in various synthetic processes, is a key intermediate in the production of novel fungicides like thifuzamide. The synthesis involves cyclization, hydrolysis, and reactions with compounds like thionyl chloride and 2,6-dibromo-4-trifluoromethoxy aniline, resulting in yields above 55.4% (Liu An-chang, 2012). Additionally, its reaction with thiosemicarbazide leads to the creation of compounds with fungicidal activities, showcasing its versatility in chemical syntheses (Zhang Ku, 2014).

Design and Synthesis of Heterocyclic CompoundsThe compound plays a significant role in the design and synthesis of constrained heterocyclic γ-amino acids, which are crucial for mimicking the secondary structures of proteins like helices and β-sheets. The synthesis process offers a highly flexible method for introducing various lateral chains, broadening its applications in drug design and molecular biology (L. Mathieu et al., 2015).

Antibacterial and Antifungal ApplicationsThe derivatives of 2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic Acid demonstrate significant antibacterial and antifungal properties. For instance, novel thiazole compounds containing an ether structure synthesized using this acid exhibit fungicidal activities against various pathogens, showcasing its potential in developing new antimicrobial agents (Qiu Li-ga, 2015).

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