1212862-77-5 | (1R)-1-[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE

CAS:1212862-77-5 | (1R)-1-[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE,Description

“®-1-(2-Methyl-3-(trifluoromethyl)phenyl)ethanamine” is an organic compound that contains a trifluoromethyl group (-CF3), which is a functional group in organofluorine chemistry. Trifluoromethyl groups are often used in medicinal chemistry due to their ability to modify the chemical properties of molecules, such as lipophilicity and metabolic stability.

Physical And Chemical Properties Analysis

The physical and chemical properties of this compound would depend on its specific structure. For example, the presence of the trifluoromethyl group could increase the compound’s lipophilicity and metabolic stability.

Scientific Research Applications

Photocatalysis and Hydrogen Production

• A study by Esswein, Veige, and Nocera (2005) discusses dihydrides formulated as Rh2(II,II)(tfepma)3H2Cl2, where tfepma stands for (bis[bis(trifluoroethoxy)phosphino]methylamine, MeN(P[OCH2CF3]2)2). These dihydrides were prepared by adding H2 to the two-electron mixed-valence complex Rh2(0,II)(tfepma)3Cl2. The research highlights a photocycle for hydrogen production involving these complexes, showcasing their potential in sustainable energy applications (Esswein, Veige, & Nocera, 2005).

Catalysis in Organic Synthesis

• Kumah, Tsaulwayo, Xulu, and Ojwach (2019) conducted structural, kinetic, and mechanistic studies on transfer hydrogenation of ketones catalyzed by chiral (pyridyl)imine nickel(II) complexes. These studies provide insights into the use of such complexes in organic synthesis, particularly in asymmetric transfer hydrogenation (Kumah et al., 2019).

Chiral Intermediate Synthesis

• Lu et al. (2022) describe the efficient synthesis of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine, a key chiral intermediate in painkillers. The study reports a bienzyme cascade system involving R-ω-transaminase and alcohol dehydrogenase for synthesizing this compound, illustrating its relevance in pharmaceutical manufacturing (Lu et al., 2022).

Ligand Synthesis and Characterization

• Canary, Allen, Castagnetto, Chiu, Toscano, and Wang (1998) synthesized ligands such as N,N-bis[(2-pyridyl)methyl]-1-(2-pyridyl)ethanamine and others. These ligands form chiral, pseudo C3-symmetric complexes with metals like ZnII and CuII, which possess potential applications in coordination chemistry and catalysis (Canary et al., 1998).

Antimicrobial and Antifungal Activity

• Pejchal, Pejchalová, and Růžičková (2015) synthesized a series of novel 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted phenyl amides. Their research demonstrated the antibacterial and antifungal activities of these compounds, highlighting their potential in developing new antimicrobial agents (Pejchal et al., 2015).

Asymmetric Synthesis and Catalysis

• Atobe, Yamazaki, and Kibayashi (2004) explored the enantioselective synthesis of primary 1-(aryl)alkylamines through nucleophilic 1,2-addition of organolithium reagents to hydroxyoxime ethers. This method was applied in asymmetric synthesis of G-protein-coupled receptor ligands, demonstrating the compound's relevance in medicinal chemistry (Atobe, Yamazaki, & Kibayashi, 2004).

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