1214344-15-6 | 2,6-DIBROMO-4-FLUOROPYRIDINE

CAS:1214344-15-6 | 2,6-DIBROMO-4-FLUOROPYRIDINE,Description

Application in Agrochemical and Pharmaceutical Industries

• Summary of the Application: Trifluoromethylpyridine (TFMP) derivatives, which can be synthesized using 2,6-Dibromo-4-fluoropyridine, are widely used in the agrochemical and pharmaceutical industries . The major use of TFMP derivatives is in the protection of crops from pests .
• Methods of Application or Experimental Procedures: The synthesis and applications of trifluoromethylpyridine (TFMP) and its derivatives involve various chemical reactions. The specific methods and procedures would depend on the desired end product .
• Results or Outcomes: Fluazifop-butyl was the first TFMP derivative introduced to the agrochemical market, and since then, more than 20 new TFMP-containing agrochemicals have acquired ISO common names . Several TFMP derivatives are also used in the pharmaceutical and veterinary industries; five pharmaceutical and two veterinary products containing the TFMP moiety have been granted market approval, and many candidates are currently undergoing clinical trials .

Synthesis of Fluorinated Pyridines

• Summary of the Application: 2,6-Dibromo-4-fluoropyridine can be used in the synthesis of fluorinated pyridines . Fluoropyridines have reduced basicity and are usually less reactive than their chlorinated and brominated analogues . They have interesting and unusual physical, chemical, and biological properties owing to the presence of the strong electron-withdrawing substituent(s) in the aromatic ring .
• Methods of Application or Experimental Procedures: The synthesis of fluorinated pyridines involves various chemical reactions. The specific methods and procedures would depend on the desired end product . For example, fluorination of pyridine by complex AlF3 and CuF2 at 450–500°C forms a mixture of 2-fluoropyridine and 2,6-difluoropyridine .
• Results or Outcomes: Fluoropyridines are used in the search for new agricultural products having improved physical, biological, and environmental properties . About 10% of the total sales of pharmaceuticals currently used for medical treatment are drugs containing a fluorine atom .

Synthesis of Active Agrochemical and Pharmaceutical Ingredients

• Summary of the Application: Trifluoromethylpyridine (TFMP) and its derivatives, which can be synthesized using 2,6-Dibromo-4-fluoropyridine, are used in the agrochemical and pharmaceutical industries . The major use of TFMP derivatives is in the protection of crops from pests . Several TFMP derivatives are also used in the pharmaceutical and veterinary industries .
• Methods of Application or Experimental Procedures: The synthesis and applications of trifluoromethylpyridine (TFMP) and its derivatives involve various chemical reactions . The specific methods and procedures would depend on the desired end product .
• Results or Outcomes: Fluazifop-butyl was the first TFMP derivative introduced to the agrochemical market, and since then, more than 20 new TFMP-containing agrochemicals have acquired ISO common names . Five pharmaceutical and two veterinary products containing the TFMP moiety have been granted market approval, and many candidates are currently undergoing clinical trials .

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