1214377-44-2 | 3-(Difluoromethoxy)-2-fluoro-pyridine

CAS:1214377-44-2 | 3-(Difluoromethoxy)-2-fluoro-pyridine,Description

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Synthesis Analysis

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Molecular Structure Analysis

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Chemical Reactions Analysis

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Physical And Chemical Properties Analysis

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Scientific Research Applications

Synthesis Enhancement

The compound 3-(Difluoromethoxy)-2-fluoro-pyridine is significant in the synthesis of various pyridine derivatives. Notably, a novel strategy for synthesizing poly-substituted 3-H, 3-F, and 3-trifluoromethyl pyridines has been developed, involving C-F bond breaking of the anionically activated fluoroalkyl group. This method yields high-quality products under metal-free conditions, enhancing pyridine synthesis efficiency (Chen et al., 2010).

Regioselective Fluorination

The compound is also utilized in the regioselective synthesis of fluorinated imidazo[1,2-a]pyridines. This process uses Selectfluor as the fluorinating agent in aqueous conditions, predominantly yielding monofluorinated products via an electrophilic fluorinated process (Liu et al., 2015).

Modular Synthesis

Additionally, the compound plays a role in the one-pot Michael addition/[5 + 1] annulation/dehydrofluorinative aromatization reaction sequence. This sequence is key for regioselective synthesis of di-, tri-, tetra-, and pentasubstituted pyridines, as well as fused pyridines, utilizing transition-metal catalyst-free conditions (Song et al., 2016).

Transformation into Fluorinated Pyridines

The synthesis of new fluorinated 3,6-dihydropyridines and 2-(fluoromethyl)pyridines is achieved through electrophilic fluorination with Selectfluor®, transforming these compounds into corresponding pyridines under mild conditions (Pikun et al., 2020).

Safety And Hazards

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Future Directions

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