122665-97-8 | 4,4-Difluorocyclohexanecarboxylic acid

CAS:122665-97-8 | 4,4-Difluorocyclohexanecarboxylic acid ,Description

4,4-Difluorocyclohexanecarboxylic acid, commonly known as 4,4-DFCA, is a carboxylic acid that is used in organic synthesis and as a reagent in a variety of scientific research applications. It is a colorless solid that is soluble in organic solvents and is used as a starting material in the synthesis of organic compounds. 4,4-DFCA is a useful reagent for the synthesis of various organic compounds and has many applications in the fields of chemistry, biochemistry, and pharmacology.
 

Scientific Research Applications

1. Building Block for Drug Discovery

4,4-Difluorocyclohexanecarboxylic acid has been identified as a promising building block in drug discovery. Its fluorinated structure is analogous to pharmacologically relevant aminocyclohexanecarboxylic acids. This compound has shown significant impact on conformation, lipophilicity, acidity, and fluorescent properties, making it a valuable compound in medicinal chemistry (Mykhailiuk et al., 2013).

2. Catalysis in Synthesis Processes

In a study focusing on catalysis, 4,4-Difluorocyclohexanecarboxylic acid was involved in the synthesis of polyhydroquinoline derivatives via Hantzsch condensation. This highlights its role in facilitating complex organic reactions, contributing to the efficient production of high-yield products in synthetic chemistry (Goli-Jolodar et al., 2016) .

3. Crystal Engineering and Supramolecular Chemistry

The compound plays a role in crystal engineering and supramolecular chemistry. It has been used in cocrystals formation with di- and tricarboxylic acids, demonstrating the ability to form various structural motifs like tapes and layered structures. These findings are important for the development of new materials with specific properties (Bhogala et al., 2005) .

4. Development of Fluorescent Probes

4,4-Difluorocyclohexanecarboxylic acid has shown potential in the development of fluorescent probes. Its incorporation into certain compounds enhances acidic and fluorescence properties, making it useful in biochemical and clinical studies. This application is particularly relevant for the detection and analysis of biological substances (Lytvyn et al., 2016).

5. Environmental Degradation Studies

In environmental science, derivatives of 4,4-Difluorocyclohexanecarboxylic acid have been studied for their degradation pathways. Understanding the environmental fate of such compounds is crucial for assessing their ecological impact and for the development of strategies to mitigate pollution (Ellis et al., 2004).

6. Polymer Science Applications

The compound has applications in polymer science, where it contributes to the synthesis of novel materials with specific properties like solubility, mechanical strength, and dielectric constants. This is particularly important for the development of advanced materials in microelectronics and other high-tech applications (Li et al., 2009).

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