1227210-35-6 | 1-broMo-4-fluoro-2-Methyl-3-nitrobenzene

CAS:1227210-35-6 | 1-broMo-4-fluoro-2-Methyl-3-nitrobenzene,Description

1-Bromo-4-fluoro-2-methyl-3-nitrobenzene is a derivative of benzene. It contains a bromo, fluoro, methyl, and nitro group attached to the benzene ring. The compound is used in the synthesis of N-fused tricyclic indoles, dimethyamine, and benzofuran.

Synthesis Analysis

The synthesis of nitro compounds like 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene can be achieved through various methods. One common method is the direct substitution of hydrocarbons with nitric acid. Another method involves displacement reactions with nitrite ions. Nitration of aromatic compounds such as benzene also takes place readily in the liquid phase.

Molecular Structure Analysis

The molecular structure of 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene can be represented by the formula C7H5BrFNO2. The compound contains a benzene ring with bromo, fluoro, methyl, and nitro substituents.

Chemical Reactions Analysis

1-Bromo-4-fluoro-2-methyl-3-nitrobenzene can undergo various chemical reactions. For instance, it can undergo a Sonogashira reaction with 2-fluoronitrobenzene to afford predominantly the bromo displacement product. It can also participate in palladium-catalyzed Stille cross-coupling reactions.

Physical And Chemical Properties Analysis

1-Bromo-4-fluoro-2-methyl-3-nitrobenzene is a solid compound with a molecular weight of 234.02. It has a density of 1.7±0.1 g/cm3. The compound has a boiling point of 236.2±35.0 °C at 760 mmHg. It has a flash point of 96.6±25.9 °C.

Scientific Research Applications

Application 1: Synthesis of Anti-Inflammatory Agents

• Summary of Application: “1-Bromo-4-fluoro-2-methyl-3-nitrobenzene” is used in the synthesis of anti-inflammatory agents. These agents are drugs or medicines that reduce inflammation or swelling.

Application 2: Synthesis of Various Compounds

• Summary of Application: “1-Bromo-4-fluoro-2-methyl-3-nitrobenzene” may be used in the synthesis of various compounds, including 6-bromo-1H-benzo[d][1,2,3]triazol-1-ol, 2-(4-bromo-2-nitrophenylamino)-5-methylthiophene-3-carbonitrile, dibenzoxazepine analog (a potent sodium channel blocker), and 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylic acid tert-butylester.

Application 3: Nomenclature of Substituted Benzene Derivatives

• Summary of Application: “1-Bromo-4-fluoro-2-methyl-3-nitrobenzene” is an example of a substituted benzene derivative. Understanding the nomenclature of such compounds is important in organic chemistry.

Application 4: Synthesis of Various Compounds

• Summary of Application: “1-Bromo-4-fluoro-2-methyl-3-nitrobenzene” may be used in the synthesis of various compounds. The specific compounds were not detailed in the source.

Application 5: Nomenclature of Substituted Benzene Derivatives

• Summary of Application: “1-Bromo-4-fluoro-2-methyl-3-nitrobenzene” is an example of a substituted benzene derivative. Understanding the nomenclature of such compounds is important in organic chemistry.

Application 6: Synthesis of Various Compounds

• Summary of Application: “1-Bromo-4-fluoro-2-methyl-3-nitrobenzene” may be used in the synthesis of various compounds. The specific compounds were not detailed in the source.

Safety And Hazards

The compound is considered hazardous according to the 2012 OSHA Hazard Communication Standard. It has hazard statements including H302 (Harmful if swallowed), H315 (Causes skin irritation), H320 (Causes eye irritation), and H335 (May cause respiratory irritation). Precautionary measures include avoiding ingestion and inhalation, avoiding dust formation, and ensuring adequate ventilation.

Future Directions

The future directions for the use of 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene could involve its use in the synthesis of more complex organic compounds. Its reactivity and the presence of multiple functional groups make it a versatile starting material for various organic reactions.

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