124700-41-0 | 2-Fluoro-5-iodobenzoic acid

CAS:124700-41-0 | 2-Fluoro-5-iodobenzoic acid,Description

Synthesis Analysis

The synthesis of related halogenated benzoic acids often involves multi-step reactions starting from simpler benzoic acid derivatives. For instance, the synthesis of 2-fluoro-6-iodobenzoic acid, a close analogue, demonstrates a typical approach involving the protection of carboxyl groups, diazotization, iodosubstitution, and deprotection steps. This process is characterized by its efficiency, low production costs, and scalability, making it suitable for commercial-scale production (Zhao Haoyu, Zhang Qimeng, & J. Tao, 2010).

Molecular Structure Analysis

The molecular structure of 2-fluoro-5-iodobenzoic acid and its derivatives is key to understanding their chemical behavior. For example, lanthanide complexes constructed from 2-fluorobenzoic acid exhibit interesting supramolecular structures and spectroscopic properties, highlighting the influence of fluorine in complex formation and stability (Dan-Dan Du, N. Ren, & Jianjun Zhang, 2021).

Chemical Reactions and Properties

2-Fluoro-5-iodobenzoic acid's reactivity is profoundly affected by its halogen substituents. The presence of fluorine and iodine allows for various chemical transformations, such as nucleophilic fluorination techniques to synthesize fluorobenzoic acids, showcasing the compound's versatility in organic synthesis (V. Zhdankin et al., 2022).

Scientific Research Applications

Generation of Electron Transfer Dissociation (ETD) Reagents via Electrospray Ionization (ESI) Followed by Collision-Induced Dissociation (CID)

• Application Summary : 2-Fluoro-5-iodobenzoic acid is used as a precursor molecule to generate ETD reagents via ESI followed by CID. ETD is a technique used in tandem mass spectrometry for the fragmentation of peptide ions.
• Results or Outcomes : The use of 2-Fluoro-5-iodobenzoic acid as a precursor molecule in this process helps in the generation of ETD reagents, which are crucial for peptide fragmentation in mass spectrometry.

Synthesis of 3, 6-Disubstituted 2-Pyridinecarboxamide (GK Activators)

• Application Summary : 2-Fluoro-5-iodobenzoic acid is used as a starting material in the synthesis of 3, 6-disubstituted 2-pyridinecarboxamide, which are known as GK activators.
• Results or Outcomes : The synthesis of 3, 6-disubstituted 2-pyridinecarboxamide (GK activators) is significant in medicinal chemistry. These compounds are known as GK activators and have potential therapeutic applications.

Preparation of 1-N-Ethyl 6-Iodoquinolonic Acid and 1-N-Cyclopropyl 6-Iodoquinolonic Acid

• Application Summary : 2-Fluoro-5-iodobenzoic acid may be used in the preparation of 1-N-ethyl 6-iodoquinolonic acid and 1-N-cyclopropyl 6-iodoquinolonic acid.
• Results or Outcomes : The preparation of 1-N-ethyl 6-iodoquinolonic acid and 1-N-cyclopropyl 6-iodoquinolonic acid is significant in organic chemistry. These compounds can be used for further chemical transformations.

Synthesis of Fluorinated Building Blocks

• Application Summary : 2-Fluoro-5-iodobenzoic acid is used in the synthesis of fluorinated building blocks.
• Results or Outcomes : The synthesis of fluorinated building blocks is significant in organic chemistry. These compounds can be used for further chemical transformations.

Preparation of Oxidizing Reagents

• Application Summary : 2-Iodobenzoic acid, a compound similar to 2-Fluoro-5-iodobenzoic acid, is used as a precursor in the preparation of oxidizing reagents like 2-iodoxybenzoic acid (IBX) and Dess-Martin periodinane (DMP).
• Results or Outcomes : The preparation of oxidizing reagents is significant in organic chemistry. These compounds can be used for various oxidation reactions.

Safety And Hazards

2-Fluoro-5-iodobenzoic acid is classified as a skin irritant (Category 2), eye irritant (Category 2), and may cause respiratory irritation (Category 3). It is recommended to avoid breathing dust/fume/gas/mist/vapors/spray and to use only outdoors or in a well-ventilated area.

More Information