125971-96-2 | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide

CAS:125971-96-2 | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide,Description

This compound serves as a crucial intermediate in synthesizing atorvastatin, a statin drug effective in lowering cholesterol and triglyceride levels. Its significance in medicinal chemistry stems from its role in the synthesis process, where it contributes to the drug's pharmacological efficacy.

Synthesis Analysis

Research highlights various synthesis routes for this compound, emphasizing its importance as an atorvastatin intermediate. Naidu and Sharma (2017) detailed the synthesis of novel impurities related to this compound, underscoring its complexity and the precision required in its synthesis to ensure purity and efficacy (Naidu & Sharma, 2017). Zhou Kai (2010) described a synthetic route starting from methyl isobutyryl acetate, illustrating a method to obtain the compound through a series of chemical reactions, including Knoevenagel condensation and Stetter reaction, with reasonable yield (Zhou Kai, 2010).

Scientific Research Applications

Summary of the Application

“2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide” is used as a key intermediate in the synthesis of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Atorvastatin has been demonstrated to be effective in reducing both triglyceride and cholesterol.

Results or Outcomes

The use of this compound as an intermediate in the synthesis of atorvastatin is well-established. Atorvastatin itself is a widely used drug for managing cholesterol levels.

Application in Impurity Synthesis

Summary of the Application

This compound has been used in the synthesis of novel impurities. Impurities are substances inside a confined amount of liquid, gas, or solid, which differ from the chemical composition of the material or compound.

Results or Outcomes

The use of this compound in the synthesis of novel impurities is a relatively new area of research. The compounds were characterized by spectral techniques such as IR, 1HNMR, 13C NMR and mass.

Future Directions

The study and application of this compound could be a potential area of research. Its unique structure and functional groups may make it interesting for various chemical, pharmaceutical, or materials science investigations.

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