1260897-05-9 | 3,3-Difluorocyclopentaecarboxylic acid

CAS:1260897-05-9 | 3,3-Difluorocyclopentaecarboxylic acid,Description

3,3-Difluorocyclopentanecarboxylic acid is a chemical compound with the molecular formula C6H8F2O2. It has a molecular weight of 150.13. It is used as an intermediate in the preparation of linked bisimidazoles, bisbenzimidazoles, and analogs.

Molecular Structure Analysis

The InChI code for 3,3-Difluorocyclopentanecarboxylic acid is 1S/C6H8F2O2/c7-6(8)2-1-4(3-6)5(9)10/h4H,1-3H2,(H,9,10). This indicates that the molecule consists of a cyclopentane ring with two fluorine atoms attached to the same carbon atom and a carboxylic acid group attached to an adjacent carbon atom.

Physical And Chemical Properties Analysis

3,3-Difluorocyclopentanecarboxylic acid is a colorless to yellow liquid or solid. It should be stored in a sealed container in a dry environment at a temperature between 2-8°C. .

Scientific Research Applications

• Deoxyfluorination of Carboxylic Acids : A bench-stable fluorination reagent, 3,3-Difluoro-1,2-diphenylcyclopropene (CpFluor), has been developed for the deoxyfluorination of carboxylic acids, transforming various carboxylic acids into acyl fluorides under neutral conditions. This method facilitates the synthesis of acyl fluorides and enables one-pot amidation reactions of carboxylic acids (Wang, Hu et al., 2021).
• Impact on Plasma Membrane Potential : Perfluorinated acids like 3,3-Difluorocyclopentanecarboxylic acid have been shown to affect cell membrane potential and intracellular pH levels. This study highlights the impact of PFAs structure on cellular processes, particularly their ability to depolarize plasma membranes and induce cytosolic acidification (Kleszczyński, Składanowski, 2009) .
• Detection in Biological Samples : Perfluorinated compounds, including those similar to 3,3-Difluorocyclopentanecarboxylic acid, have been detected in human plasma samples. This raises concerns about environmental exposure and potential health risks associated with these compounds (Fromme, Wöckner et al., 2017).
• Analytical Methodologies : Advanced analytical methodologies have been developed for the detection and quantification of perfluorinated carboxylic acids in environmental and biological samples. These methods are crucial for monitoring the presence and impact of such compounds in the environment (Poboży, Krol et al., 2010) .
• Biodegradation Studies : Research on the biodegradation of compounds like 3,3-Difluorocyclopentanecarboxylic acid has shown the formation of various transformation products. Understanding these degradation pathways is important for assessing the environmental fate of such compounds (Wang, Szostek et al., 2005).

Safety And Hazards

The compound is labeled with the GHS07 pictogram, indicating that it can cause harm if swallowed, inhaled, or if it comes into contact with skin. It can also cause eye irritation. Precautionary measures include avoiding breathing dust/fume/gas/mist/vapors/spray and washing thoroughly after handling.

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