1262410-84-3 | 1-Boc-3-fluoropyrrolidine-3-Methanol

CAS:1262410-84-3 | 1-Boc-3-fluoropyrrolidine-3-Methanol,Description

Molecular Structure Analysis

The molecular formula of Tert-butyl 3-fluoro-3-(hydroxymethyl)pyrrolidine-1-carboxylate is C10H18FNO3. The Inchi Code is 1S/C10H18FNO3/c1-9(2,3)15-8(14)12-5-4-10(11,6-12)7-13/h13H,4-7H2,1-3H3/t10-/m1/s1.

Physical And Chemical Properties Analysis

The molecular weight of Tert-butyl 3-fluoro-3-(hydroxymethyl)pyrrolidine-1-carboxylate is 219.26. It is an oil at room temperature. The storage temperature is recommended to be in a refrigerator.

Scientific Research Applications

Enzymatic Metabolism Studies

One significant application of Tert-butyl 3-fluoro-3-(hydroxymethyl)pyrrolidine-1-carboxylate derivatives is in the study of enzymatic metabolism. For instance, the in vitro metabolism of a related compound, 1-[2-(5-tert-butyl-[1,3,4] oxadiazole-2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone, was investigated using rat liver microsomes. This study focused on identifying the major metabolic pathways, which included hydroxylation and carbonyl reduction, providing insight into how similar compounds are metabolized in biological systems (Yoo et al., 2008).

Antibacterial Agent Synthesis

Compounds structurally similar to Tert-butyl 3-fluoro-3-(hydroxymethyl)pyrrolidine-1-carboxylate have been explored for their potential as antibacterial agents. For example, a series of fluoronaphthyridines and quinolones with tert-butyl and pyrrolidine substitutions were synthesized and showed promise as antibacterial agents due to their structure-activity relationships. These studies highlight the potential of such compounds in the development of new antibacterial drugs (Bouzard et al., 1992; Di Cesare et al., 1992).

Asymmetric Synthesis

Another application is found in asymmetric synthesis. For instance, the enantioselective synthesis of N-tert-butyl disubstituted pyrrolidines was achieved via a nitrile anion cyclization strategy. This method was applied to synthesize (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3-carboxylic acid, demonstrating the compound's utility in producing chiral pyrrolidine derivatives with high yield and enantiomeric excess (Chung et al., 2005).

Anti-Inflammatory Research

In the field of anti-inflammatory research, derivatives of Tert-butyl 3-fluoro-3-(hydroxymethyl)pyrrolidine-1-carboxylate have been synthesized and evaluated for their potential as anti-inflammatory agents. For example, compounds like 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones were found to have dual inhibitory activity on prostaglandin and leukotriene synthesis, indicating their possible use in anti-inflammatory and analgesic therapies (Ikuta et al., 1987).

Safety And Hazards

The safety information includes the following hazard statements: H302, H315, H319, H335. The precautionary statements include P264, P270, P301, P301, P312, P330. The signal word is “Warning” and it is classified under the GHS07 pictogram.

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