13089-11-7 | Methyl Trifluoropyruvate

CAS:13089-11-7 | Methyl Trifluoropyruvate ,Description

Methyl trifluoropyruvate (MTP) is an organofluorine compound, which is a colorless liquid at room temperature and is used in various scientific applications. It is a simple, yet powerful reagent that can be used in a variety of synthetic and biochemical methods. MTP has been used in a variety of applications, including synthetic organic chemistry, biochemistry, and drug discovery.
 

Scientific Research Applications

Versatility in Organic Synthesis

MTFP has been highlighted for its dual functionality in organic reactions, serving both as an electrophile and a nucleophile. This dual functionality broadens its application in creating complex organic molecules. For instance, MTFP has been utilized in the optimized laboratory-scale preparation of itself from industrial precursors, showcasing its importance in synthetic chemistry due to the unique properties conferred by the trifluoromethyl group (Dolenský et al., 2002)[https://consensus.app/papers/methyl-333trifluoropyruvate-procedure-starting-dolenský/6c6caf2dad075c269e2469f26125ae9a/?utm_source=chatgpt ].

Application in Nucleophilic Reactions

The preparation and synthetic application of a novel ketene silyl acetal derived from MTFP highlight its utility in carbon-carbon bond formation through various nucleophilic reactions. This approach allows for the synthesis of coupling products with high yields, showcasing MTFP's role in facilitating complex synthetic pathways (Takikawa et al., 2005)[https://consensus.app/papers/preparation-application-ketene-silyl-methyl-takikawa/32a68133bad85ab4998867cdf202483b/?utm_source=chatgpt].

Enantioselective Synthesis

In enantioselective synthesis, MTFP has been employed in the Friedel-Crafts alkylation of indoles, pyrroles, and furans, catalyzed by chiral phosphoric acid. This method exemplifies the incorporation of the trifluoromethyl group into biologically active molecules, an aspect of considerable interest in pharmaceutical research (Kashikura et al., 2010)[https://consensus.app/papers/friedelcrafts-alkylation-indoles-pyrroles-furans-kashikura/de538f75441a5aa495ea67560dce224a/?utm_source=chatgpt].

Chemical Properties and Reactivity

The study of the conformational landscape and chemical reactivity of MTFP, through high-resolution rotational spectroscopy, provides insights into its structural properties and the effects of the trifluoromethyl group on its reactivity. Such studies are essential for understanding the fundamental properties that make MTFP a valuable compound in chemical synthesis (Lengsfeld et al., 2020)[https://consensus.app/papers/barrier-rotation-symmetry-carbonyl-reactivity-methyl-lengsfeld/936a34184702564b84b14ba6e2585b2d/?utm_source=chatgpt].

Synthesis of Amino Acid Derivatives

MTFP has been used as a precursor for synthesizing a variety of α-CF3-α-amino acid derivatives. These derivatives have potential applications as drug candidates, showcasing MTFP's role in the development of novel pharmaceutical compounds (Skarpos et al., 2006)[https://consensus.app/papers/methyltrifluoropyruvate-imines-possessing-noxalyl-skarpos/2e8a334e43fa54ecb156a2d7c2184818/?utm_source=chatgpt].

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