1314400-72-0 | 5-Trifluoromethyl-1H-Pyrrole-2-Carboxylic Acid

CAS:1314400-72-0 | 5-Trifluoromethyl-1H-Pyrrole-2-Carboxylic Acid,Description

Molecular Structure Analysis

The molecular structure of a compound can be determined using various techniques, but specific data for 5-(Trifluoromethyl)-1H-pyrrole-2-carboxylic acid is not available in the literature.

Physical And Chemical Properties Analysis

The physical and chemical properties of a compound include its acidity, solubility, and stability. For instance, the introduction of a formyl group into position “2” of boronic acids, similar to 5-(Trifluoromethyl)-1H-pyrrole-2-carboxylic acid, causes a significant increase in acidity.

Scientific Research Applications

Crystal Structure Analysis

5-(Trifluoromethyl)-1H-pyrrole-2-carboxylic acid's derivatives have been studied for their crystal structures. For instance, the crystal structure of a related compound, 5-(trifluoromethyl)picolinic acid monohydrate, showcases a water-bridged hydrogen-bonding network. This research contributes to understanding the molecular geometry and intermolecular interactions of such compounds, which is crucial in materials science and drug design (Ye & Tanski, 2020).

Synthesis of HIV-1 Entry Inhibitors

5-Arylpyrrole-2-carboxylic acids, structurally related to 5-(Trifluoromethyl)-1H-pyrrole-2-carboxylic acid, have been identified as key intermediates in the synthesis of HIV-1 entry inhibitors, such as NBD-11021 and NBD-14010. These compounds play a significant role in developing treatments for HIV (Belov et al., 2017).

Catalysis and Chemical Reactions

Pyrrole-2-carboxylic acid, a compound similar to 5-(Trifluoromethyl)-1H-pyrrole-2-carboxylic acid, has been utilized as a ligand in Cu-catalyzed reactions involving primary anilines and aryl halides. This demonstrates its potential in facilitating important chemical transformations (Altman et al., 2008).

Preparation of Novel Compounds

Research has also focused on preparing novel pyrrole derivatives containing a pentafluorosulfanyl group, which could yield compounds with potential utility in various chemical applications. Such explorations expand the scope of compounds available for scientific study and potential industrial applications (Dolbier & Zheng, 2009).

Antiviral Research

Compounds structurally related to 5-(Trifluoromethyl)-1H-pyrrole-2-carboxylic acid have been explored for their potential in antiviral research, particularly in inhibiting HIV-1 fusion and targeting gp41. This indicates the potential of such compounds in developing new antiviral therapies (Jiang et al., 2011).

Safety And Hazards

Safety data sheets provide information about the potential hazards of a compound and how to handle it safely. For related compounds, it is advised to avoid breathing dust/fume/gas/mist/vapors/spray, to wash skin thoroughly after handling, and to use only outdoors or in a well-ventilated area.

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