131747-41-6 | 2-(Trifluoromethyl)isonicotinic acid

CAS:131747-41-6 | 2-(Trifluoromethyl)isonicotinic acid ,Description

2-(Trifluoromethyl)isonicotinic acid, commonly referred to as TFMA, is an organic compound that is widely used in scientific research. It is a derivative of isonicotinic acid and can be synthesized from the reaction of isonicotinic acid and trifluoroacetic acid. TFMA is a potent inhibitor of enzymes such as acetylcholinesterase, monoamine oxidase A, and monoamine oxidase B, and has been studied for its potential applications in medicinal chemistry, biochemistry, and pharmacology.
 

Scientific Research Applications

Homometallic and Heterometallic Molecular Topologies

2-(Trifluoromethyl)isonicotinic acid is used in the construction of molecular topologies. It has been shown to participate in the formation of homometallic and heterometallic molecular squares, demonstrating its role in the creation of complex molecular structures (Teo et al., 2004).

Luminescence Properties

This compound is valuable in the study of luminescence. It has been used to synthesize coordination complexes with silver, exhibiting excellent fluorescence properties. These complexes have potential applications in fluorescence probing and in studies related to microsecond diffusion and dynamics of membranes (Yuan & Liu, 2005).

Trifluoromethylation Process

In electrochemical studies, 2-(Trifluoromethyl)isonicotinic acid has been investigated for its trifluoromethylation properties. This research explores its behavior under different electrochemical conditions, contributing to the understanding of its reactions and applications in various chemical processes (RajaBeryl & Xavier, 2018).

Photocatalytic Degradation

Isonicotinic acid derivatives, including 2-(Trifluoromethyl)isonicotinic acid, have been utilized in enhancing the photocatalytic degradation efficiency of certain metal-organic frameworks (MOFs). These MOFs show a significant increase in the degradation of organic pollutants, demonstrating the compound's potential in environmental applications (Zulys et al., 2022).

Magnetic Properties of MOFs

The compound is instrumental in the synthesis of metal-organic frameworks that exhibit unique magnetic properties, such as antiferromagnetic behavior. This highlights its role in the development of materials with specific magnetic characteristics (Zhou et al., 2020).

Charge Transfer Dynamics

Studies involving 2-(Trifluoromethyl)isonicotinic acid have also delved into the charge transfer dynamics in aromatic molecules. This research is crucial in understanding electron transfer processes, which has implications in semiconductor technology and photochemical devices (Schnadt et al., 2003).

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