131748-14-6 | 4-Chloro-2-(Trifluoromethyl)pyridine

CAS:131748-14-6 | 4-Chloro-2-(Trifluoromethyl)pyridine ,Description

4-Chloro-2-(Trifluoromethyl)pyridine, otherwise known as CTP, is a heterocyclic organic compound that has been widely used in scientific research. It is a colorless liquid with a strong, unpleasant odor and is highly volatile. CTP has been used in a variety of applications, including synthetic organic chemistry, medicinal chemistry, and biochemistry. It is a versatile reagent that can be used for a variety of reactions, such as nucleophilic aromatic substitution and Friedel-Crafts alkylation. Additionally, it has been used in the synthesis of drugs and other pharmaceutical compounds.
 

Scientific Research Applications

Synthesis and Chemical Reactions

• 4-Chloro-2-(Trifluoromethyl)pyridine is a key intermediate in the synthesis of various compounds, including the highly efficient herbicide trifloxysulfuron, achieved through a process involving Hofmann degradation, oxidative chlorination, and diazotization-alcoholysis (Zuo Hang-dong, 2010).
• It undergoes site-selective electrophilic substitutions, serving as a starting material for further chemical manipulations, including halogen/metal exchange and electrophilic trapping (F. Mongin et al., 1998).
• The compound is also utilized in various synthetic methods for producing related pyridines used in pharmaceuticals, agrochemicals, and biochemicals (Li Zheng-xiong, 2004).

Functionalization and Metalation

• 4-Chloro-2-(Trifluoromethyl)pyridine has been explored for its potential in the regioexhaustive functionalization, where it can be converted into various carboxylic acids, demonstrating its versatility in organic synthesis (F. Cottet & M. Schlosser, 2004).
• The compound displays distinct reactivity towards lithium reagents, allowing for its selective metalation and subsequent functionalization at different positions, making it a valuable building block in life-sciences-oriented research (M. Schlosser & Marc Marull, 2003).

Spectroscopic and Structural Studies

• Structural and spectroscopic properties, including FT-IR, NMR, and vibrational frequencies, have been characterized for 2-chloro-6-(trifluoromethyl)pyridine. These studies contribute to a deeper understanding of its molecular structure and behavior in different conditions (M. Evecen et al., 2017).
• Detailed experimental and computational studies, including vibrational spectrum analysis and density functional theory (DFT) calculations, have been conducted to understand the physical and chemical properties of 4-(Trifluoromethyl)pyridine-2-carboxylic acid (H. Vural, 2016).

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