13252-13-6 | 2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoic acid

CAS:13252-13-6 | 2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoic acid ,Description

2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoic acid (TFPPA) is a fluoroalkyl ester of carboxylic acid that is widely used in various scientific research applications. It has been found to be useful in the synthesis of various compounds, and has been used in various biological and biochemical experiments. It is a versatile compound that has a wide range of applications in the field of science and technology.
 

Scientific Research Applications

1. Absorption, Distribution, Metabolism, and Excretion in Animal Models

• Application: Studied for its pharmacokinetic behavior in rats, mice, and monkeys. GenX is rapidly and completely absorbed, not metabolized, and eliminated exclusively in the urine. These studies are crucial in understanding its behavior in living organisms (Gannon et al., 2016).

2. Aquatic Toxicity and Environmental Impact

• Application: Evaluated for its aquatic toxicity and bioaccumulation potential. This research is significant for environmental risk assessments and understanding the impact on aquatic life (Hoke et al., 2016).

3. Phytotoxicity in Plants

• Application: Investigated for its effects on plant growth and photosynthesis. Studies on Arabidopsis thaliana and Nicotiana benthamiana show that GenX can inhibit plant growth and induce oxidative stress (Chen et al., 2019).

4. Chronic Toxicity and Carcinogenicity in Rats

• Application: Assessed for its potential chronic toxicity and carcinogenicity in animal models. This research provides insights into the long-term health effects of GenX exposure (Rae et al., 2015).

5. Immunomodulatory Effects in Mice

• Application: Studied for its effects on the immune system. This research is important for understanding the potential health implications of GenX exposure (Rushing et al., 2017).

6. Environmental Distribution and Contamination

• Application: Investigated for its occurrence in river systems and environmental contamination. This is crucial for understanding the environmental spread and impact of GenX (Heydebreck et al., 2015).

7. Comparative Toxicity with Other PFAS

• Application: Compared with other perfluoroalkyl acids for toxic potency. This research helps in understanding the relative risks of different fluorinated compounds (Gomis et al., 2018).

8. Interaction with Human Proteins

• Application: Analyzed for its binding mechanism with human serum albumin, providing insights into its potential effects on human health (Delva‐Wiley et al., 2021) .

9. Epigenetic Toxicity in Cell Models

• Application: Explored for its epigenetic effects in liver cell models. This research is crucial for understanding the molecular mechanisms of GenX-induced toxicity (Wen et al., 2020).

10. Transcriptomic Responses in Mice Livers

• Application: Investigated for its effects on liver gene expression in mice. This research contributes to understanding the specific molecular pathways affected by GenX (Heintz et al., 2022).

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