133331-77-8 | 1-(Perfluorohexyl)octane

CAS:133331-77-8 | 1-(Perfluorohexyl)octane ,Description

1-(Perfluorohexyl)octane, or PFHxO, is a synthetic organic compound with a carbon backbone of eight carbons and six fluorine atoms attached to the terminal carbon. It is a member of the perfluoroalkyl group of compounds and is used in a variety of applications. PFHxO is a colorless, odorless, and non-flammable liquid with a boiling point of 100°C (212°F). It is relatively insoluble in water and is miscible with most organic solvents. 
 

Scientific Research Applications

Toxicity and Safety in Medical Devices

• Acute Retinal Toxicity: Studies have indicated that a mixture containing perfluorooctane and perfluorohexyloctane can cause acute retinal toxicity. This was observed in cases of vitreoretinal surgery using this mixture as an endotamponade, leading to severe visual loss and retinal necrosis (Barton, Chodosh, & Jonas, 2018); (Pastor et al., 2017); (Coco et al., 2018).

Applications in Organic Synthesis

• Electrophilic Fluorinating Agents: 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), a related compound, is used as a site-selective electrophilic fluorinating agent in organic synthesis. It's one of the more user-friendly agents compared to other aggressive or toxic reagents (Banks, 1998) .

Ophthalmic Surgery Applications

• Vitreous Tamponade in Surgery: Perfluorocarbon liquids like perfluorohexyloctane are used for hydrokinetic retinal manipulation in vitreoretinal surgery. They can act as a vitreous substitute, but there is a concern regarding their long-term effects on the retina and other eye structures (Zeana et al., 2004).

Chemical Synthesis and Analysis

• Methacryloyl Monomers Synthesis: Perfluorohexyl iodide, a related compound, has been used in the preparation of novel methacryloyl monomers containing aromatic rings and short perfluorocarbon side chains. These monomers are significant in chemical industries and research (Wang Ming-gang, 2012).
• Purity Analysis in Ophthalmic Operations: The purity of Perfluorooctane, used in ophthalmic operations, has been analyzed using qualitative methods like FID (Flame Ionization Detector). This is crucial for maintaining quality control in medical applications (Minzhu Wang, Li Zhang, & Menglan Qian, 2012).

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