13642-97-2 | Pentafluorophenyl methacrylate

CAS:13642-97-2 | Pentafluorophenyl methacrylate ,Description

Pentafluorophenyl methacrylate (PFMA) is a widely used monomer in the polymer industry. It has unique properties that make it a valuable material for a variety of applications, including the synthesis of polymers, adhesives, coatings, and elastomers. The unique structure of PFMA provides a number of advantages and limitations for lab experiments and research.
 

Scientific Research Applications

1. Multifunctional Polymer Synthesis

Pentafluorophenyl methacrylate (PFMA) serves as a key component in the synthesis of multifunctional polymers. It has been polymerized to create soluble polymeric active esters, which are highly reactive towards primary and secondary amines, as well as alcohols. These polymers have been used to prepare multifunctional materials, demonstrating their versatility in polymer chemistry (Eberhardt et al., 2005).

2. Surface Reactivity in Biomedical Applications

PFMA has shown remarkable surface reactivity, particularly in biomedical contexts. Ultrathin layers of PFMA deposited through pulsed-plasma polymerization have been studied for their reactivity with biomolecules like amines and proteins. This reactivity makes PFMA a candidate for biomedical surface coatings and immobilization of biomolecules (Francesch et al., 2007).

3. Biomolecule Immobilization

PFMA's ability to immobilize biomolecules has been explored, particularly using plasma polymerized PFMA. This method allows for the covalent binding of biologically active peptides and proteins, making PFMA a valuable tool in the field of biochemistry and molecular biology (Duque et al., 2010).

4. Kinetic Studies in Copolymerization

Recent studies have investigated the kinetics of copolymerization involving PFMA, especially in creating materials for biomedical applications. This includes studying the reversible addition fragmentation chain transfer (RAFT) copolymerization, providing insights into the rate of incorporation and control over copolymer composition (Alex et al., 2021).

5. RAFT Polymerization and Linear Diblock Copolymers

PFMA has been used in RAFT polymerization processes to create linear diblock copolymers. This method has successfully yielded polymers that can react with amines, forming multifunctional polymers, which are significant in materials science and engineering (Eberhardt & Théato, 2005).

6. Nanogel Formation for Drug Delivery

PFMA has been instrumental in forming redox-responsive nanogels, useful in controlled drug delivery. These nanogels can encapsulate and release hydrophobic drugs, showing potential for significant advancements in pharmaceutical applications (Noree et al., 2017).

7. Detection in Biological Systems

The use of PFMA in nanoparticle detection within biological systems, particularly in blood plasma, has been explored. This includes developing methods like ELISA for detecting peptide-functionalized nanoparticles, highlighting PFMA's role in nanomedicine and diagnostic research (Bode et al., 2015).

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