13682-77-4 | Potassium vinyltrifluoroborate

CAS:13682-77-4 | Potassium vinyltrifluoroborate ,Description

Potassium vinyltrifluoroborate (KVF) is a chemical compound composed of potassium, vinyltrifluoroborate, and a variety of other chemical components. It is an important chemical compound in the field of organic synthesis and has a wide range of applications in organic synthesis, pharmaceuticals, and chemical engineering. KVF is a highly reactive compound and is used in the synthesis of a wide range of organic compounds.
 

Scientific Research Applications

• Synthesis of 2H-Chromene Derivatives: Potassium vinyltrifluoroborates have been used effectively to synthesize 2-substituted 2H-chromene derivatives from salicylaldehyde, with yields ranging from 70-90%. These derivatives are potential candidates for TGF-β receptor inhibitors, highlighting their significance in pharmaceutical research (Liu, Evans, & Das, 2008).
• Rh(III)-Catalyzed Annulations: In a study on Rh(III)-catalyzed annulations, potassium vinyltrifluoroborate was effectively paired with benzamide derivatives. This resulted in the production of 4-trifluoroboratotetrahydroisoquinolones with complementary regioselectivity, showcasing its utility in organic synthesis (Presset et al., 2013).
• Palladium-Catalyzed Cross-Coupling Reactions: Substituted potassium internal vinyltrifluoroborates have been effectively used in palladium-catalyzed cross-coupling reactions with aryl and heteroaryl halides. This application is promising for pharmaceutical research, offering a versatile method for synthesizing complex organic molecules (Math et al., 2012).
• Carbonylative 1,4-Addition of Vinyl Ketones: Potassium aryltrifluoroborates have been shown to act as a proton source for the carbonylative 1,4-addition of vinyl ketones. This broadens their scope in homogeneous catalysis, enhancing the versatility of these compounds in organic synthesis (Sauthier et al., 2009).
• Development of a 1,2-Dianion Equivalent: The utilization of potassium vinyltrifluoroborate in the development of a unique 1,2-diboraethane has been reported. This compound serves as a building block for linking two electrophiles via palladium-catalyzed Suzuki-Miyaura cross-couplings, underscoring its potential in organic synthesis (Molander & Sandrock, 2009).
• Synthesis of Vinyl-Substituted Polypyridines: Potassium vinyltrifluoroborate has been used in the Suzuki-Miyaura cross-coupling with bromopolypyridines. This process facilitates the straightforward synthesis of vinyl-substituted polypyridines, which have potential applications in reductive electropolymerization (Nie, Yao, & Zhong, 2011).

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