1369769-03-8 | 6-chloro-3-fluoropyridin-2-ol

CAS:1369769-03-8 | 6-chloro-3-fluoropyridin-2-ol,Description

6-Chloro-3-fluoropyridin-2-OL (6-CFP) is an organic compound belonging to the class of pyridinols. It is a colorless, water-soluble solid with a molecular formula of C5H4ClFO. 6-CFP is a versatile molecule with many potential applications in the fields of organic synthesis, medicinal chemistry, and materials science. It has been used in a variety of research studies to investigate its properties and to develop new methods for its synthesis. 
 

Scientific Research Applications

Fluorine-18 Labelling in Medical Imaging

6-Chloro-3-fluoropyridin-2-OL and similar compounds are utilized in the medical imaging technique of Positron Emission Tomography (PET). Particularly, the fluorine-18 labelling of fluoropyridines, which includes 6-chloro-3-fluoropyridin-2-OL, is significant due to its potential stability and utility in vivo, overcoming limitations associated with other positions of fluorine on the pyridine ring (Carroll et al., 2007) .

Synthesis and Chemical Transformation

The compound has been studied for its synthesis and transformation potential. Starting from different precursors, such as 3,5-dichloro-2,4,6-trifluoropyridine, it can be transformed into various other compounds, demonstrating its flexibility and utility in chemical synthesis (Mi Zhi-yuan, 2010).

Radiopharmaceutical Research

It serves as a precursor in the synthesis of novel radioligands. For instance, compounds derived from 6-chloro-3-fluoropyridin-2-OL have been used to develop radioligands for studying extrathalamic nicotinic acetylcholine receptors using PET (Zhang & Horti, 2004).

Antibacterial Agent Synthesis

Studies have shown its involvement in the synthesis of antibacterial agents. The compound acts as a building block in the creation of various naphthyridine derivatives with potential antibacterial properties (Matsumoto et al., 1984).

Structural and Isomerization Studies

Research has also focused on the compound's role in creating structural manifolds and studying isomerization reactions. These studies provide insights into the flexibility and reactivity of halopyridines, which are crucial for developing new pharmaceuticals and materials (Schlosser & Bobbio, 2002).

Conformational and Tautomeric Studies

The compound has been a subject in the study of conformational landscapes and tautomeric equilibria, which are fundamental in understanding the behavior of molecules under different conditions. This research is essential in the field of molecular spectroscopy and quantum chemistry (Calabrese, 2015).

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