1421372-94-2 | N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine

CAS:1421372-94-2 | N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine,Description

N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine, commonly referred to as FMNPA, is a small molecule that has been widely studied for its potential biological effects. It is a derivative of the indole nucleus, which is an important structural element found in many natural products and is known to possess a variety of biological activities. FMNPA has been studied for its potential use in drug discovery, as a potential therapeutic agent, and as a tool to study various biochemical and physiological processes. 
 

Scientific Research Applications

Intermediate in Antitumor Drug Synthesis

Phenyl compounds related to N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine are significant intermediates in the synthesis of antitumor drugs. A related compound, phenyl (6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-yl)carbamate, was synthesized as an important intermediate in small molecular inhibitors for anti-tumor applications. The synthesis involved acylation and nucleophilic substitution from 6-chloropyrimidine-4-amine and the structures of intermediates were confirmed using MS and 1H NMR techniques (Gan et al., 2021).

Antifungal Activity

Pyrimidine derivatives containing the nitrophenyl group have demonstrated significant antifungal effects. Compounds similar to N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine, like 4-chloro-6-methoxy-N, N-dimethylpyrimidin-2-amine derivatives, showed promising biological activity against fungi such as Aspergillus terreus and Aspergillus niger (Jafar et al., 2017).

Potential in Drug Design Against Chronic Myeloid Leukemia

N-(2-methyl-5-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine, a compound structurally related to the one , was identified as a potential template for drug design against chronic myeloid leukemia (CML). The compound was synthesized and analyzed for its crystal structure, spectroscopic, and electronic properties. It demonstrated potential interactions important in the inhibition process of CML, suggesting its applicability in drug design (Moreno-Fuquen et al., 2021).

Radiosensitizing Effect in Cancer Therapy

N-phenylpyrimidin-2-amine derivatives, structurally similar to the compound , have been studied for their radiosensitizing effects on human lung cancer cells. These compounds, when combined with radiation, showed a significant decrease in clonogenic survival and inhibited multiple CDKs involved in cell cycle regulation. This indicates their potential as treatments to improve the effectiveness of radiotherapy in cancer patients (Jung et al., 2019).

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