1434127-01-1 | tert-butyl N-[(3S,4S)-3-fluoropiperidin-4-yl]carbamate

CAS:1434127-01-1 | tert-butyl N-[(3S,4S)-3-fluoropiperidin-4-yl]carbamate,Description

Molecular Structure Analysis

The molecular formula of “tert-butyl N-[(3S,4S)-3-fluoropiperidin-4-yl]carbamate” is C10H20N2O3. The exact mass is 216.14739250 g/mol. The compound has 2 hydrogen bond donors and 4 hydrogen bond acceptors. The compound has a complexity of 225.

Physical And Chemical Properties Analysis

The compound has a molecular weight of 216.28 g/mol. It has a topological polar surface area of 73.6 Ų. The compound has a rotatable bond count of 3. The physical form of a similar compound, “tert-butyl N-[(3S,4S)-3-aminooxan-4-yl]carbamate”, is a white to yellow solid.

Scientific Research Applications

• Synthesis and Chemical Transformation :
  • Zhao et al. (2017) detailed the synthesis of a tert-butyl carbamate derivative, emphasizing its role as an intermediate in biologically active compounds like omisertinib (Zhao, Guo, Lan, & Xu, 2017).
  • Tang et al. (2014) synthesized (R)-tert-butyl carbamate as an intermediate of jaspine B, a natural product with cytotoxic activity against human carcinoma cell lines (Tang, Liu, Qin, Wang, Li, Huang, & Wang, 2014).
  • Sakaitani and Ohfune (1990) discussed the chemoselective transformation of amino protecting groups via tert-butyldimethylsilyl carbamates, highlighting their utility in organic synthesis (Sakaitani & Ohfune, 1990).
• Biological and Pharmacological Applications :
  • Camarillo-López et al. (2020) explored a tert-butyl carbamate derivative’s potential in treating Alzheimer's disease, focusing on its β-secretase and acetylcholinesterase inhibitory activities (Camarillo-López, Hernández Rodríguez, Torres-Ramos, Arciniega-Martínez, García-Marín, Correa Basurto, Méndez Méndez, & Rosales-Hernández, 2020) .
  • Ghosh, Cárdenas, and Brindisi (2017) described enantioselective syntheses of tert-butyl carbamate derivatives for potential use as protease inhibitors (Ghosh, Cárdenas, & Brindisi, 2017).
• Chemical Structure and Properties :
  • Kant, Singh, and Agarwal (2015) conducted synthetic and crystallographic studies on tert-butyl carbamate derivatives, offering insights into their molecular structure and interactions (Kant, Singh, & Agarwal, 2015).
  • Zheng et al. (2008) analyzed the crystal structure of a tert-butyl carbamate derivative to better understand its molecular conformation (Zheng, Huang, Guo, Zhang, & Jin, 2008).

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