1449521-05-4 | (Triphenylphosphonio)difluoroacetate

CAS:1449521-05-4 | (Triphenylphosphonio)difluoroacetate ,Description

(Triphenylphosphonio)difluoroacetate, also known as PFA, is an organofluoride compound used in various scientific research applications. It is a colorless solid that is soluble in many organic solvents and has a low melting point. PFA is a versatile reagent, with many applications in the synthetic chemistry, biochemistry and pharmacology fields. It is used in a variety of processes, including synthesis, reaction mechanisms, and biochemical and physiological studies.
 

Scientific Research Applications

Synthesis of Organic Compounds

(Triphenylphosphonio)difluoroacetate (PDFA) plays a crucial role in the synthesis of various organic compounds. A study demonstrated that the reaction of indoline-2,3-diones with PDFA yielded novel 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles, which are valuable in producing other trifluoromethylated oxindole derivatives (Liu et al., 2016).

Development of Analytical Methods

PDFA has been instrumental in developing new analytical methods. For example, a study used it in a gas chromatography and mass spectrometry procedure for detecting fluoroacetic acid and phenoxy acid herbicides. This triphasal extractive method demonstrated high sensitivity and could detect these compounds in various mediums, including beverages (Miki et al., 1998).

Reactions with Transition Metals

PDFA is involved in reactions with transition metals, indicating its utility in organometallic chemistry. One study explored its interactions with group vib triphenylphosphonium (tricarbonylmetal)cyclopentadienylides, leading to insights into the Lewis basicity of transition metals (Kotz & Pedrotty, 1970).

Mitochondrion-Targeting Molecules

In the field of medicinal chemistry, derivatives of triphenylphosphonium cations, such as those labeled with 64Cu, have been studied for their potential in targeting mitochondria in cancer cells. This research is significant for developing new diagnostic and therapeutic strategies (Kim et al., 2008).

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