1478-53-1 | Diethyl (difluoromethyl)phosphonate

CAS:1478-53-1 | Diethyl (difluoromethyl)phosphonate ,Description

Diethyl (difluoromethyl)phosphonate (DFP) is a difluoromethyl-substituted phosphonate ester that has been used for a variety of purposes in scientific research. It is an important chemical reagent and is used in a wide range of synthetic applications. It has been used as a key intermediate in the synthesis of a variety of biologically active compounds, including drugs, pesticides, and polymers. DFP has also been used to study the mechanism of action of various enzymes and proteins.
 

Scientific Research Applications

• Synthesis of Alkynes: Diethyl (dichloromethyl)phosphonate is utilized in the synthesis of specific alkynes, acting as an intermediate in this process (Marinetti & Savignac, 2003).
• Facilitating Access to Hydroxy-Difluorophosphonates: Diethyl (difluoro(trimethylsilyl)methyl)phosphonate aids in accessing various hydroxy-difluorophosphonates, which are potential targets for medicinal research (Wang, Cao, & Zhou, 2016).
• Emmons-Horner Wittig Reagent: Diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate is an effective reagent for converting aldehydes and ketones into compounds with high E selectivity (Netz & Seidel, 1992).
• Difluoromethylation Precursor: Diethyl bromodifluoromethylphosphonate serves as an efficient and environmentally friendly difluoromethylation precursor for phenols and thiophenols (Zafrani, Sod-Moriah, & Segall, 2009).
• Corrosion Inhibition Properties: Diethyl (phenylamino) methyl) phosphonate derivatives exhibit notable corrosion inhibition properties for carbon steel, particularly effective in acidic mediums (Moumeni et al., 2020).
• Production of Difluomlefins: Diethyl 2-oxo-1,1-difluorophosphonates are synthesized to produce 1,1-difluomlefins, useful in various applications (Tsai, 1997).
• Phosphonate Geometry and Bonding: Diethyl (1-hydroxy-2-butynyl)phosphonate displays nearly tetrahedral geometry around the phosphorus atom, involving intermolecular and intramolecular hydrogen bonding (Sanders et al., 1996).
• Difluoromethylation of Tertiary Amines: A practical method for the difluoromethylation of tertiary amines using diethyl bromodifluoromethylphosphonate and fluoride is presented, with potential applications in fine chemicals (Zafrani et al., 2016).
• Synthesis of Aryl(difluoromethyl)phosphonic Esters: A new DAST-free route enables the synthesis of phenols with (diethoxyphosphonyl)difluoromethyl groups, offering new possibilities in synthesis without using the DAST reagent (Blades et al., 1996).
• Stereoselective Synthesis of Esters: Sequential transformations of phosphonate facilitate the highly stereoselective synthesis of perfluoroalkylated alpha-fluoro-alpha,beta-unsaturated esters (Shen & Ni, 1997).

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