1478-61-1 | Bisphenol AF

CAS:1478-61-1 | Bisphenol AF ,Description

Bisphenol AF (BPAF) is a chemical compound that has been used in a variety of industrial and consumer products since the 1960s. It is a synthetic analog of the naturally occurring Bisphenol A (BPA), and is used in the production of plastics, paints, adhesives, and other products. BPAF has also been used in medical and scientific research, as it has been found to have a range of biochemical and physiological effects on cells and organisms.
 

Scientific Research Applications

Endocrine and Estrogenic Activity

Bisphenol AF (BPAF) has been studied for its role as an endocrine-disrupting chemical. Matsushima et al. (2010) found that BPAF acts as a full agonist for the estrogen receptor ERα and a specific antagonist for ERβ, suggesting its potential to perturb physiological processes mediated through these receptors (Matsushima et al., 2010).

Effects on Human Red Blood Cells

A study by Maćczak et al. (2016) investigated the eryptotic changes in human erythrocytes exposed to BPAF. Their findings indicated that BPAF, along with other bisphenols, could induce eryptosis, suggesting potential health implications (Maćczak et al., 2016) .

Metabolic and Adipogenic Effects

Skledar et al. (2019) examined BPAF and its main metabolite, BPAF-glucuronide, for their influence on estrogen receptor activity and adipogenesis. Their research suggested that BPAF-G is not an inactive metabolite and called for further toxicological investigations of BPAF's effects on human health (Skledar et al., 2019).

Impact on Oocyte Maturation

Ding et al. (2017) demonstrated that BPAF can negatively affect oocyte maturation in mice, disrupting spindle morphology and inducing oxidative stress and DNA damage. This finding highlights BPAF's potential impact on female fertility (Ding et al., 2017).

Steroidogenic Gene Expression and Hormone Synthesis

Research by Feng et al. (2016) on the H295R cell line revealed that BPAF, along with other bisphenol analogues, can alter steroidogenesis, affecting hormone production and gene expression. This study contributes to understanding the endocrine-disrupting action of BPAF (Feng et al., 2016).

Long-term Effects on Zebrafish

Shi et al. (2015) explored the long-term effects of BPAF on hormonal balance and genes in zebrafish, finding significant changes in hormone levels and gene expression. Their study indicated potential reproductive and developmental impacts of BPAF exposure (Shi et al., 2015).

Neurodevelopmental and Neurotoxic Effects

Coumailleau et al. (2020) and Lee et al. (2013) examined the neurodevelopmental and neurotoxic effects of BPAF, demonstrating its impact on neurobehavioral development in zebrafish and inducing apoptosis in neuronal cells. These findings highlight the neurotoxic properties of BPAF (Coumailleau et al., 2020); (Lee et al., 2013).

Fetal Abnormalities

Tuzimski et al. (2023) investigated the association between bisphenol residues in amniotic fluid and fetal abnormalities, providing potential clinical applications in the context of human biomonitoring studies (Tuzimski et al., 2023).

Uptake and Bioconcentration in Zebrafish

Shi et al. (2016) studied the uptake, depuration, and bioconcentration of BPAF in zebrafish, providing insights into the environmental impact and risks of BPAF in aquatic ecosystems (Shi et al., 2016) .

Environmental Occurrence and Profiles

Song et al. (2014) reported on the occurrence and profiles of bisphenol analogues, including BPAF, in municipal sewage sludge in China, contributing to the understanding of environmental exposure to these chemicals (Song et al., 2014).

Molecular Mechanisms and Risk Assessment

Li et al. (2018) and Delfosse et al. (2012) provided insights into the molecular mechanisms of BPAF and its impact on estrogen receptor-mediated transcriptional activation, aiding in risk assessment and the discovery of safer BPA substitutes (Li et al., 2018); (Delfosse et al., 2012).

Toxicity Comparisons and Membrane Affinity

Russo et al. (2018) compared the cytotoxicity of several bisphenol analogues, including BPAF, and investigated their membrane affinity, providing valuable information for industrial applications and risk assessments (Russo et al., 2018).

Toxicity Evaluation Using Biosensors

Zhu et al. (2020) developed a micro-biosensor for evaluating the toxicity of BPAF and other bisphenols, contributing to rapid and sensitive toxicity assessment methods (Zhu et al., 2020).

Ecological Risks in Aquatic Environments

Liu et al. (2020) reviewed the occurrence, toxicity, and ecological risk of BPAF and other bisphenols in aquatic environments, providing a comprehensive perspective on their environmental impact (Liu et al., 2020).

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