148043-73-6 | 4,4,5,5,5-Pentafluoropentan-1-ol

CAS:148043-73-6 | 4,4,5,5,5-Pentafluoropentan-1-ol ,Description

4,4,5,5,5-Pentafluoropentan-1-ol, also known as pentafluoropentanol (PFPOH), is a fluorinated alcohol with a five-membered ring structure. It is a colorless, odorless, and highly volatile liquid that is soluble in many organic solvents. PFPOH is a versatile molecule with a variety of applications in the areas of synthetic organic chemistry, biochemistry, and pharmacology. In particular, it is widely used in the synthesis of organic compounds, such as pharmaceuticals, agrochemicals, and polymers. Additionally, it has been used in the development of various biochemical and physiological effects. 
 

Scientific Research Applications

Synthesis and Chemical Reactions

• Synthesis of Anti-Cancer Agents: A study by Li, Provencher, and Singh (1994) describes the synthesis of 4,4,5,5,5-Pentafluoropentan-1-thiol, a chain in anti-breast cancer agents, through a free radical addition process and catalytic hydrogenation. This highlights its role in developing potential cancer treatments (Li, Provencher, & Singh, 1994).
• Formation of Quinolines: Hosokawa et al. (2008) investigated the synthesis of 3-fluoro-4-(trifluoromethyl)quinolines using pentafluoropropen-2-ol, showing its utility in creating complex organic structures (Hosokawa, Matsumura, Katagiri, & Uneyama, 2008).
• Halocyclization Mechanisms: Cui and Brown (2000) explored the halocyclization reaction of 4-penten-1-ol, providing insights into the reaction mechanisms and influences of various substituents (Cui & Brown, 2000).
• Catalytic Reactions with Alkynes: A study by Pouy et al. (2012) examined the intramolecular addition of O–H and N–H bonds across carbon-carbon triple bonds, where 4-pentyn-1-ol was a key component (Pouy, Delp, Uddin, Ramdeen, Cochrane, Fortman, Gunnoe, Cundari, Sabat, & Myers, 2012).

Physical and Chemical Properties

• Molecular Structure Analysis: Trætteberg et al. (1985) investigated the molecular structure and conformation of 4-penten-1-ol, contributing to the understanding of its chemical behavior (Trætteberg, Bakken, Seip, Lüttke, & Knieriem, 1985) .
• Rheological Properties: Hetalo et al. (2020) studied the rheological properties of fluorinated alcohols, including the structure and behavior of molecules like 4,4,5,5,5-Pentafluoropentan-1-ol (Hetalo, Khorolskyi, Stetsenko, Samoilenko, & Svechnikova, 2020).

Miscellaneous Applications

• Photophysical Properties: Raj, Biju, and Reddy (2008) synthesized tris(beta-diketonate)europium(III) complexes using a derivative of 4,4,5,5,5-Pentafluoropentan-1-ol, showcasing its application in photophysical studies (Raj, Biju, & Reddy, 2008).
• Computational Studies: Sheng, Musaev, Reddy, McDonald, and Morokuma (2002) conducted computational studies on the cycloisomerization of 4-pentyn-1-ol, highlighting the role of computational methods in understanding chemical reactions involving such compounds (Sheng, Musaev, Reddy, McDonald, & Morokuma, 2002).

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