148992-43-2 | 1-Ethoxy-2,2-difluoroethanol

CAS:148992-43-2 | 1-Ethoxy-2,2-difluoroethanol ,Description

1-Ethoxy-2,2-difluoroethanol (EDFE) is an organic compound that has been used in synthesis reactions and research applications since its discovery in the late 1950s. It is a colorless, volatile liquid with a molecular weight of 166.05 g/mol and a boiling point of 84 °C. EDFE is a versatile compound that has the potential to offer a wide range of applications in research and industry. 
 

Scientific Research Applications

Surface Chemistry and Reactions

1-Ethoxy-2,2-difluoroethanol plays a role in surface chemistry, particularly on aluminum oxide surfaces. Vaynberg and Ng (2005) studied its adsorption and thermal decomposition on high-surface-area Al2O3, finding that it decomposes to form fluorinated surface ethoxide at specific temperatures. This decomposition process involves surface isolated hydroxyl groups (Vaynberg & Ng, 2005).

Synthesis of Trifluoromethyl-Substituted Heteroarenes

The compound serves as a building block for creating trifluoromethyl-substituted compounds. Sommer et al. (2017) demonstrated its use in synthesizing various heteroarenes, including thiophenes, furans, and pyrrols. This synthesis is significant for pharmaceutical and material science applications (Sommer et al., 2017).

Formation of Metallophthalocyanines

GÜrol, Gümüş, and Ahsen (2012) explored the synthesis of novel fluoroether-substituted phthalocyanines using 1-Ethoxy-2,2-difluoroethanol. This process leads to the creation of metal-free and metallophthalocyanines, important in the development of materials for electronics and other technologies (GÜrol, Gümüş, & Ahsen, 2012) .

Diels-Alder Reactions

The compound has been used in Diels-Alder reactions, as studied by Volle and Schlosser (2002). They examined its use in creating functionalized (trifluoromethyl)benzenes and -pyridines, highlighting its versatility in organic synthesis (Volle & Schlosser, 2002).

Photochemical Isomerization

Barlow et al. (1982) investigated the photochemical isomerization of related fluoroether compounds. Their research contributes to understanding the chemical behavior of these compounds under various conditions (Barlow et al., 1982).

Ethoxylation Processes

Radhakrishnan, Franken, and Martens (2012) explored the ethoxylation of alkenes using bioethanol over zeolite beta catalysts. This research is crucial for understanding the industrial application of fluoroethers in synthesizing green chemicals (Radhakrishnan, Franken, & Martens, 2012).

Direct Introduction of CF2Me Moiety

Carbonnel et al. (2019) highlighted the importance of fluoroether compounds in introducing the CF2Me moiety directly into various molecules. This process is significant in pharmaceuticals and material sciences (Carbonnel et al., 2019).

Protection of Hydroxyl Groups

Wu, Shull, and Koreeda (1996) developed a method using fluoroether compounds for the protection of hydroxyl groups in various chemical reactions. This research is important for synthetic chemistry, especially in protecting sensitive groups in complex molecules (Wu, Shull, & Koreeda, 1996).

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