1514-82-5 | 2-Bromo-3,3,3-trifluoroprop-1-ene

CAS:1514-82-5 | 2-Bromo-3,3,3-trifluoroprop-1-ene ,Description

2-Bromo-3,3,3-trifluoroprop-1-ene (also referred to as 2-BTP) is an organic compound belonging to the class of halogenated hydrocarbons. It is a colorless liquid with a sweet, pungent odor and a boiling point of 115°C. 2-BTP has been used in various scientific research applications due to its unique properties, such as its low vapor pressure, low solubility in water, and high stability. 
 

Scientific Research Applications

• Synthesis of α-(Trifluoromethyl)styrenes: This compound is utilized in the generation of thermally unstable vinyllithium by lithiation, which then undergoes borylation in a flow microreactor system. The resultant vinylborate is directly used for the Suzuki–Miyaura coupling, yielding α-(trifluoromethyl)styrenes in high yields (Fujita et al., 2018).
• Syntheses of CF3-Containing Allylic Alcohols and Amines: It involves a rapid lithium-halogen-exchange reaction, generating vinyllithium which reacts with more reactive electrophiles to afford 2-(trifluoromethyl)allyl alcohols and N-[2-(trifluoromethyl)allyl] sulfoamides. This methodology allows for the synthesis of various CF3-containing compounds, which have significance in medicinal chemistry (Nadano et al., 2010).
• Preparation of 3,3,3-Trifluoropropene Oxide (TFPO): This compound is used in the bromination of 3,3,3-trifluoropropene followed by treatment with acetic acid to produce 2-bromo-3,3,3-trifluoropropyl acetate, which on further processing yields TFPO (Ramachandran & Padiya, 2007).
• Photocatalytic Reactions: 2-Bromo-3,3,3-trifluoropropene has been employed as a coupling partner in photocatalytic defluorinative reactions, leading to the formation of various difluoromethylidene-tetrahydroquinolines (Zeng et al., 2022).
• Electrochemical Carboxylation: It's involved in electrochemical carboxylation processes that lead to the efficient fixation of carbon dioxide, yielding corresponding 2-aryl-3,3,3-trifluoropropanoic acids. This method has been applied to synthesize β,β,β-trifluorinated non-steroidal anti-inflammatory drugs (Yamauchi, Hara & Senboku, 2010).

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