1514-87-0 | Methyl chlorodifluoroacetate

CAS:1514-87-0 | Methyl chlorodifluoroacetate ,Description

Methyl chlorodifluoroacetate (MCDF) is an organic compound with the molecular formula CHF2CO2CH3. It is a colorless, volatile liquid that is used as a reagent in organic synthesis and for the preparation of fluorinated compounds. MCDF has a wide range of applications in scientific research and laboratory experiments. In 
 

Scientific Research Applications

• Trifluoromethylation of Saturated Organic Halides: Methyl chlorodifluoroacetate is used for trifluoromethylation of saturated organic halides, providing a method to create trifluoromethyl derivatives. This is important in synthetic chemistry for modifying organic compounds (Qing‐Yun Chen & Jian-Xing Duan, 1993).
• Generation of Trifluoromethylcopper: It serves in the generation of trifluoromethyl copper reagent, important in organic synthesis for producing trifluoromethyl aromatic compounds (J. Macneil & D. Burton, 1991).
• Trifluoromethylating Agent: Used as a convenient trifluoromethylating agent, facilitating the production of trifluoromethyl derivatives, which are valuable in various synthetic applications (Qing‐Yun Chen, D. Su & Jian-Xing Duan, 1991).
• Synthesis of Anti-Infective Agents: Plays a key role in the synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate, an intermediate in creating novel anti-infective agents (J. Mulder et al., 2013).
• Atmospheric Sink Study: Investigated for its role in atmospheric chemistry, particularly its reaction with chlorine atoms, contributing to our understanding of atmospheric processes and pollutant behavior (M. B. Blanco et al., 2016).
• Esterification Processes: Used in esterification reactions, specifically in the synthesis of methyl chlorodifluoroacetate from 1,2-dichloro-1,1,2-trifluoro-2-methoxyethane, showcasing its utility in organic synthesis (H. Quan et al., 2001).
• Herbicide Research: Although not directly about methyl chlorodifluoroacetate, this study on selective weed-killers highlights the broader context of research in chemical synthesis and application in agriculture (G. E. Blackman, 1945).
• Difluorocyclopropanes Synthesis: Useful in the synthesis of gem-difluorocyclopropanes, indicating its importance in creating specialized organic compounds (G. A. Wheaton & D. Burton, 1977) .
• Spectroscopy Studies: Analyzed for its microwave spectrum, contributing to the understanding of molecular structures and dynamics (B. Long et al., 2011).
• Coupling Reactions in Organic Synthesis: Utilized in coupling reactions with carbonyl compounds, demonstrating its value in creating complex organic molecules (T. Ishihara et al., 1991).

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