1522-22-1 | Hexafluoroacetylacetone

CAS:1522-22-1 | Hexafluoroacetylacetone ,Description

Hexafluoroacetylacetone (HFA) is a highly reactive, volatile, and toxic chemical compound with a molecular formula of C2F6O2. It is a colorless liquid that has a characteristic, pungent odor and is soluble in water, ethanol, and chloroform. HFA is used as a reagent in organic synthesis, as a catalyst in organic reactions, and as a fluorinating agent in the production of fluorinated compounds. It is also used in the production of pharmaceuticals, pesticides, surfactants, and other specialty chemicals.
 

Scientific Research Applications

• Molecular Structure and Stability: Hexafluoroacetylacetone is a ‘rigid’ molecule, distinct from acetylacetone, with a high barrier to internal motions and a stable enolic Cs form. It has a well-defined molecular structure as determined through rotational spectra and ab initio calculations (Evangelisti et al., 2009).
• Photochemistry and Photoproducts: Upon UV irradiation, hexafluoroacetylacetone produces CO among other photoproducts. This transformation is significant in understanding its photochemical behavior (Kusaba & Tsunawaki, 2007).
• Separation of Uranium and Lanthanides: It effectively separates lanthanides from uranium matrices, providing a simplified and efficient process for isolating target elements (Rego et al., 2015).
• Infrared Spectra of Metal Chelate Compounds: Its metal chelate compounds have distinct infrared spectra, aiding in the understanding of complex formations with various metals (Morris et al., 1963).
• Thermochromatographic Separation: Hexafluoroacetylacetonates are useful for the transport and separation of short-life isotopes of metallic elements, demonstrating their applicability in nuclear chemistry (Fedoseev et al., 1987) .
• Catalytic Activity Tuning in Metal–Organic Frameworks: Incorporating hexafluoroacetylacetone in metal–organic frameworks alters the selectivity and activity of catalysts, particularly in ethylene hydrogenation processes (Liu et al., 2019).
• Hydrogen Bond Analysis: The analysis of its infrared spectra provides insights into the hydrogen-bonding characteristics and force constants in its structure (Ogoshi & Nakamoto, 1966) .
• Surface Chemistry: Its interaction with surfaces like Cu(210) reveals complex chemistry and potential for low-temperature copper etching, important in material science (Nigg & Masel, 1998).
• Matrix-Isolation Technique in Photoisomerization: Low-temperature matrix-isolation techniques combined with UV irradiation show its structural transformation and stability under different conditions (Nagashima et al., 2003) .
• Multinuclear Copper Complexes: The study of its complexes, like the 11-nuclear copper complex, aids in understanding the structural chemistry of metal-organic complexes (Romanenko et al., 2019).

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