1522-41-4 | Ethyl 2-fluoroacetoacetate

CAS:1522-41-4 | Ethyl 2-fluoroacetoacetate ,Description

Ethyl 2-fluoroacetoacetate (E2FAA) is a synthetic compound with a wide range of applications in scientific research. It is a versatile compound that can be used for a variety of purposes, including as a reagent for organic synthesis, a precursor for drug synthesis, a catalyst for biochemical reactions, and a molecule for studying the effects of fluoroacetate. It is an important tool for researchers in the fields of biochemistry, physiology, pharmacology, and toxicology.
 

Scientific Research Applications

• Metabolism and Toxicity Studies: Fraser and Pattison (1955) prepared ethyl ω-fluoroacetoacetate to compare with acetoacetic acid, predicting its interference with fatty acid metabolism and potential toxicity due to its structural similarity to certain acids (Fraser & Pattison, 1955) .
• Enantioselective Hydrogenation: Szőri, Szöllősi, and Bartók (2006) described the enantioselective hydrogenation of racemic ethyl 2-fluoroacetoacetate using a Cinchona alkaloid-modified platinum catalyst. This method is significant for producing optically enriched α-fluoro-β-hydroxy esters (Szőri, Szöllősi, & Bartók, 2006) .
• Photooxidation in Environmental Chemistry: Blanco et al. (2010) investigated the Cl-initiated photooxidation of a series of fluoroacetates, including ethyl 2-fluoroacetoacetate, to study their atmospheric implications (Blanco et al., 2010).
• Lithium Battery Research: Nambu and Sasaki (2015) explored the physical and electrolytic properties of monofluorinated ethyl acetates, including ethyl 2-fluoroacetoacetate, for application in lithium secondary batteries (Nambu & Sasaki, 2015).
• Catalysis in Organic Synthesis: Zhao, Tian, and Zhao (2017) utilized new chiral sulfinamide ligands in Pd-catalyzed asymmetric allylic alkylations of ethyl 2-fluoroacetoacetate to obtain fluorinated allyl products (Zhao, Tian, & Zhao, 2017).
• Medical and Toxicological Research: Sikorski, Dmochowski, and Safian (1992) presented a case study on accidental fatal poisoning with ethyl fluoroacetate, discussing the toxicological aspects and health hazards (Sikorski, Dmochowski, & Safian, 1992).
• Chemical Synthesis: Xu, Shi, Zhou, Wang, Zhang, Song, and Deng (2015) reported a one-pot synthesis of monofluorinated 4-H-pyran derivatives using ethyl 2-fluoroacetoacetate (Xu et al., 2015).
• Cancer Research: Riadi, Alamri, Geesi, Anouar, Ouerghi, Alabbas, Alossaimi, Altharawi, Dehbi, and Alqahtani (2021) synthesized a new derivative of ethyl 2-fluoroacetoacetate for evaluation as a dual inhibitor for VEGFR-2 and EGFR tyrosine kinases in cancer treatment (Riadi et al., 2021).

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