1544-85-0 | 2,2-Difluorobenzo[d][1,3]dioxol-5-amine

CAS:1544-85-0 | 2,2-Difluorobenzo[d][1,3]dioxol-5-amine ,Description

2,2-Difluorobenzo[d][1,3]dioxol-5-amine, commonly referred to as DFBO, is an organic compound with a wide range of applications in the scientific and medical fields. It is a colorless, crystalline solid that is soluble in water and has a high melting point. DFBO is one of the most widely used organic compounds in the world, and its properties make it useful in a variety of applications.
 

Scientific Research Applications

• Medicinal Chemistry: The 2,2-difluorobenzodioxole moiety is used in medicinal chemistry as a metabolically more stable derivative of the benzodioxole fragment. It has potential applications in drug synthesis and medicinal research (Catalani, Paio, & Perugini, 2010).
• Synthesis of Nitroso-Compounds: 2,2-Difluoroaniline and related amines can be oxidized to nitroso-compounds, indicating its utility in the synthesis of specific organic compounds (Nunno, Florio, & Todesco, 1970).
• Fluorous Deoxy-Fluorination Reagent: A novel fluorous deoxy-fluorination reagent derived from this compound has been developed for the fluorination of alcohols and diols, highlighting its role in the development of new chemical reagents (Furuya, Nomoto, Fukuhara, & Hara, 2009).
• Photovoltaic Properties: The compound is used in the synthesis of donor–acceptor polymers, affecting physical, optoelectronic, and photovoltaic properties. This includes applications in polymer solar cells (Wang, Xin, Lu, Xiao, Xu, Zhao, Hu, Ong, & Ng, 2013).
• High-Performance Polymers: Modified poly(ether-imide)s bearing pendent benzimidazole, benzoxazole, or benzothiazole groups have been prepared using derivatives of this compound, indicating its use in the development of high-performance polymers (Toiserkani, 2011).
• Low Dielectric Materials: It has been used in synthesizing fluorinated polybenzoxazines, leading to materials with low dielectric constants, high thermal stability, and low moisture absorption, suitable for high-temperature processes in electronics (Parveen, Thirukumaran, & Sarojadevi, 2014).
• Photopolymerization Initiator: As a hydrogen-abstraction photoinitiator, it has been shown to be effective in the kinetics of photopolymerization, suggesting its application in polymer science (Cui, Wang, Ma, Qian, Yang, Yu, & Nie, 2011).
• Chemoselective Synthesis: It has been used as a synthon for chemoselective preparation of compounds in drug discovery programs (Colella, Musci, Carlucci, Lillini, Tomassetti, Aramini, Degennaro, & Luisi, 2018).
• Antitumor Activities: Derivatives of this compound have been synthesized and evaluated for their antitumor activities, indicating its potential in cancer research (聂瑶, 黄东海王发松, 但悠梦, 赵金顺, 宋新建, Yao, Dong-hai, Fa-song, You-meng, Jin-shun, & Xinjian, 2014) .
• Novel Antitumor Prodrugs: Amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles have been developed, suggesting its use in developing water-soluble, chemically stable prodrugs (Bradshaw, Bibby, Double, Fichtner, Cooper, Alley, Donohue, Stinson, Tomaszewjski, Sausville, & Stevens, 2002).

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