154590-35-9 | 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline

CAS:154590-35-9 | 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline,Description

The compound tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate is a derivative of piperazine, which is a common scaffold in medicinal chemistry due to its versatility and biological relevance. Piperazine derivatives are known for their potential in mimicking peptide helices and serving as intermediates in the synthesis of biologically active compounds.

Synthesis Analysis

The synthesis of related

Scientific Research Applications

Chemical Synthesis and Characterization

• Tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate has been synthesized and characterized through various methods. A study focused on the synthesis and characterization of a related compound, tert-butyl 4-(5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl) piperazine-1-carboxylate, providing insights into its molecular structure and intermolecular interactions (Sanjeevarayappa et al., 2015).

Crystal Structure Analysis

• The crystal structure of tert-butyl 4-[4-(4-fluorophenyl)-2-methylbut-3-yn-2-yl]piperazine-1-carboxylate has been analyzed, shedding light on the sterically congested piperazine structure and its potential pharmaceutical applications (Gumireddy et al., 2021).

Synthesis of Derivatives

• Research has also focused on synthesizing various derivatives of tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate, exploring their potential as intermediates in the synthesis of biologically active compounds, such as benzimidazole derivatives (Ya-hu, 2010).

Antibacterial and Anthelmintic Activity

• Some studies have evaluated the antibacterial and anthelmintic activities of tert-butyl piperazine derivatives, revealing moderate activity in these areas, which could be relevant for pharmaceutical research (Kulkarni et al., 2016).

Anticorrosive Properties

• Tert-butyl piperazine derivatives have been studied for their anticorrosive properties, particularly in protecting carbon steel surfaces in corrosive media. This highlights its potential industrial applications in materials science (Praveen et al., 2021).

Pharmaceutical Research

• Piperazine derivatives, including tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate, are being investigated for their potential as core structures in pharmaceutical research. Their unique molecular configurations may lead to the development of new drugs (Nowak et al., 2015).

Safety And Hazards

The compound is considered hazardous according to the 2012 OSHA Hazard Communication Standard. It has hazard statements including H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H332 (Harmful if inhaled), and H335 (May cause respiratory irritation).

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