1547-87-1 | N,N-DIMETHYLTRIFLUOROACETAMIDE

CAS:1547-87-1 | N,N-DIMETHYLTRIFLUOROACETAMIDE,Description

Synthesis Analysis

The synthesis of compounds related to 2,2,2-Trifluoro-N,N-dimethylacetamide often involves the use of trifluoroacetylated precursors or direct fluorination techniques. For example, the preparation of perfluoro-[N-(4-pyridyl)acetamide], involving direct fluorination of sodium salts of perfluoro-[N-(4-pyridyl)-acetamide], demonstrates a method that could potentially be adapted for the synthesis of 2,2,2-Trifluoro-N,N-dimethylacetamide (Banks et al., 1996).

Molecular Structure Analysis

Investigations into the molecular structure of related compounds, such as N-(2,3-dihydroxy-4-iodo-2,3-dimethylbutyl)trifluoroacetamide, have shown the importance of hydrogen bonds in stabilizing the molecular structure in both crystal and solution phases (Sterkhova et al., 2019). These structural insights could inform the analysis of 2,2,2-Trifluoro-N,N-dimethylacetamide's molecular geometry.

Chemical Reactions and Properties

The chemical reactivity of 2,2,2-Trifluoro-N,N-dimethylacetamide derivatives, such as its involvement in oxidative addition reactions to alkenes and dienes, reveals its potential for creating iodinated and other functionalized products under specific conditions (Shainyan et al., 2015). These reactions underscore the compound's versatility in synthetic chemistry applications.

Physical Properties Analysis

The physical properties of 2,2,2-Trifluoro-N,N-dimethylacetamide, and its analogs, are significantly influenced by their fluorinated structures. For instance, the study on excess enthalpies of mixtures containing 2,2,2-trifluoroethanol highlights the impact of fluorination on intermolecular interactions and thermodynamic properties (Pikkarainen, 1988).

Chemical Properties Analysis

The chemical properties of 2,2,2-Trifluoro-N,N-dimethylacetamide derivatives, including reactivity towards nucleophilic and electrophilic agents, demonstrate a broad range of functional capabilities. Oxidative trifluoromethylthiolation of terminal alkynes with AgSCF3, for example, showcases an efficient method to synthesize alkynyl trifluoromethyl sulfides, indicating the potential chemical versatility of the trifluoromethyl group in such molecules (Zhu et al., 2014).

Scientific Research Applications

• GC-MS Analysis

  • Field : Analytical Chemistry
  • Application : 2,2,2-Trifluoro-N,N-dimethylacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS (Gas Chromatography-Mass Spectrometry) analysis.
  • Method : The compound is used to react with the sample to be analyzed, forming volatile derivatives. These derivatives are then analyzed using GC-MS, a technique that separates and identifies different substances within a test sample.
  • Results : This method allows for the detection and identification of various substances within a sample. The specific results would depend on the sample being analyzed.

• Lithium Metal Battery Research

  • Field : Material Science
  • Application : 2,2,2-Trifluoro-N,N-dimethylacetamide has been used in the research of lithium metal batteries.
  • Method : The compound is used in the electrolyte with the aim of forming a stable Solid-Electrolyte Interphase (SEI) to protect the lithium metal anode.
  • Results : The research found that the electrolyte with 2,2,2-Trifluoro-N,N-dimethylacetamide could potentially improve the stability and performance of lithium metal batteries.

Safety And Hazards

This compound is classified as a flammable liquid and vapor. It can cause skin and serious eye irritation. Safety measures include keeping the container tightly closed, using explosion-proof electrical/ventilating/lighting equipment, and wearing protective gloves/eye protection/face protection. In case of fire, dry sand, dry chemical, or alcohol-resistant foam should be used to extinguish.

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