161622-05-5 | 3-Fluoro-5-(trifluoromethyl)benzoic acid

CAS:161622-05-5 | 3-Fluoro-5-(trifluoromethyl)benzoic acid,Description

Synthesis Analysis

The synthesis of fluorinated benzoic acid derivatives involves various chemical processes. In a study by (Zhou et al., 2007), a mesogen compound closely related to 3-Fluoro-5-(trifluoromethyl)benzoic acid was synthesized, highlighting the complex nature of producing such fluorinated compounds.

Molecular Structure Analysis

The molecular structure of such compounds is characterized by the presence of fluorine atoms, which significantly influence their physical and chemical properties. For instance, the study by (Zhou et al., 2007) discusses how the fluorinated compound exhibits a unique sequence of isotropic, cubic, and hexagonal columnar phases.

Chemical Reactions and Properties

Fluorinated benzoic acids participate in various chemical reactions due to the presence of the reactive carboxylic acid group and the influence of fluorine atoms. (Seki & Ohkura, 1992) describe the photosubstitution of a fluorinated uracil compound, demonstrating the reactivity of such fluorinated structures.

Physical Properties Analysis

The physical properties of 3-Fluoro-5-(trifluoromethyl)benzoic acid and similar compounds are heavily influenced by their fluorination. For example, (Xie et al., 2001) discuss how the presence of fluorine imparts excellent thermal stability and low moisture absorption in related polyimides.

Chemical Properties Analysis

The chemical properties of fluorinated benzoic acids are unique due to the electronegative nature of fluorine. This aspect is explored in studies like (Ichikawa et al., 2002), which describe the utilization of fluorine's properties in synthetic chemistry.

Scientific Research Applications

General Uses 3-Fluoro-5-(trifluoromethyl)benzoic acid is a benzoic acid derivative featuring a fluoride and a trifluoromethyl at the 3- and 5-positions, respectively. It is employed in the synthesis of active pharmaceutical ingredients (APIs) due to the excellent lipophilicity and binding affinity provided by the fluorinated substituents. As a benzoic acid building block, 3-fluoro-5-(trifluoromethyl)benzoic acid can be easily attached to molecule scaffolds through amination reactions. The carboxylic acid group can be converted to an acyl chloride for nucleophilic substitution and Friedel-Craft acylation.

Specific Application One specific application of 3-Fluoro-5-(trifluoromethyl)benzoic acid is in the creation of a fusion inhibitor of influenza A virus, based on oligothiophene. The product exhibits an inhibition of 0.22 µM on the membrane fusion between the virus and the endosome of the host cells.

Safety And Hazards

The compound is classified as an irritant, with hazard statements H315, H319, and H335 indicating that it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Safety measures include wearing personal protective equipment, ensuring adequate ventilation, and avoiding contact with skin, eyes, and clothing.

Relevant Papers Unfortunately, the search results do not provide specific papers related to 3-Fluoro-5-(trifluoromethyl)benzoic acid.

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