Purchase CAS:162401-70-9,view related peer-reviewed papers,technical documents,similar products,MSDS & more. 4-(Difluoromethoxy)-3-methoxybenzaldehyde (4-DFMOB) is an organic compound that belongs to the class of arylaldehydes. It is a colorless solid with a molecular weight of 218.2 g/mol and a boiling point of 221°C. 4-DFMOB is an important intermediate in the synthesis of pharmaceuticals, agricultural chemicals, and other ...
4-(Difluoromethoxy)-3-methoxybenzaldehyde (4-DFMOB) is an organic compound that belongs to the class of arylaldehydes. It is a colorless solid with a molecular weight of 218.2 g/mol and a boiling point of 221°C. 4-DFMOB is an important intermediate in the synthesis of pharmaceuticals, agricultural chemicals, and other organic compounds. It is also used as a reagent in the synthesis of a variety of organic compounds, including polymers, dyes, and polysaccharides.
Scientific Research Applications
Synthesis and Characterization of Derivatives:
Synthesis of 4-Benzyloxy-2-Methoxybenzaldehyde: A study detailed the synthesis of this compound through O-alkylation and Vilsmeier-Hack (V-H) reactions, achieving an overall yield of 82.26% (Lu Yong-zhong, 2011).
Investigation on 4-Hexyloxy-3-Methoxybenzaldehyde: Research involved spectroscopic and quantum chemical investigations on this compound, analyzing its geometry, vibrational frequencies, and molecular electrostatic potential (A. Abbas, H. Gökce, S. Bahçelī, 2016).
Molecular Interactions and Properties:
Interactions in 4-Methoxybenzaldehyde: A study focused on the structural and electronic properties of 4-methoxybenzaldehyde, exploring its intermolecular interactions and molecular docking behaviors, particularly its inhibitory activity on tyrosinase (H. Ghalla, Noureddine ISSAOUI, F. Bardak, A. Atac, 2018).
Charge Transfer Effects on 4-Hydroxy-3-Methoxybenzaldehyde: This research examined the spectral characteristics of the compound in different solvents and its interaction with beta-cyclodextrin (N. Rajendiran, T. Balasubramanian, 2008).
Synthetic Methods and Applications:
Facile Synthesis of 3-Fluoro-4-Methoxybenzaldehyde: A simplified one-step synthesis method for this compound was developed, highlighting its potential for industrial application (Wang Bao-jie, 2006).
Reductive Electrophilic Substitution of Derivatives: The study reported on the selective removal and substitution of the methoxy group in derivatives of 3,4,5-trimethoxybenzaldehyde, demonstrating potential for creating specific chemical structures (U. Azzena, G. Melloni, A. M. Piroddi, E. Azara, S. Contini, E. Fenude, 1992).
Pharmacological and Biological Activities:
Anti-Asthmatic Activity of Phenolic Compounds: One study examined the anti-asthmatic activities of phenolic compounds, including 4-hydroxy-3-methoxybenzaldehyde, highlighting the roles of hydroxy and methoxy radicals in these activities (Young-Woon Jang, J. Lee, Chang Jong Kim, 2010).
Electrochemical Sensing and Analysis:
Electrochemical Sensing of Vanillin: This research explored the use of fluorine-doped reduced graphene oxide decorated with gold nanoparticles for the detection of vanillin (4-hydroxy-3-methoxybenzaldehyde), a related compound, demonstrating its potential in sensor applications (V. Manikandan, E. Boateng, Sharmila Durairaj, Aicheng Chen, 2022).