1628265-17-7 | 2-chloro-4-(4-fluorophenyl)thiazole-5-carbonitrile

CAS:1628265-17-7 | 2-chloro-4-(4-fluorophenyl)thiazole-5-carbonitrile,Description

2-Chloro-4-(4-fluorophenyl)thiazole-5-carbonitrile is a chemical compound with the molecular formula C10H4ClFN2S. It is a solid substance.

Molecular Structure Analysis

The InChI code for 2-Chloro-4-(4-fluorophenyl)thiazole-5-carbonitrile is 1S/C10H4ClFN2S/c11-10-14-9(8(5-13)15-10)6-1-3-7(12)4-2-6/h1-4H. This indicates that the molecule consists of a thiazole ring (a five-membered ring containing nitrogen and sulfur) attached to a fluorophenyl group and a nitrile group.

Physical And Chemical Properties Analysis

2-Chloro-4-(4-fluorophenyl)thiazole-5-carbonitrile has a predicted boiling point of 426.5±55.0 °C and a predicted density of 1.50±0.1 g/cm3.

Scientific Research Applications

• Antimicrobial Activity :
  • Synthesized derivatives of 2-Chloro-4-(4-fluorophenyl)thiazole have been studied for their antimicrobial properties. These compounds demonstrated significant activity against Gram-negative and Gram-positive bacteria, as well as fungi like Aspergillus niger and Candida albicans (Badiger et al., 2013).
• Synthesis of Novel Compounds :
  • Novel Schiff bases using derivatives of 2-Chloro-4-(4-fluorophenyl)thiazole have been synthesized. These compounds exhibited in vitro antimicrobial activity, with some showing excellent activity compared to other derivatives (Puthran et al., 2019).
• Crystallographic Analysis :
  • Dihydrofuran carbonitrile derivatives, including those with structural similarities to 2-Chloro-4-(4-fluorophenyl)thiazole, were analyzed using X-ray crystallography. These studies provided insights into the coordinated compliance of chloro-methyl and bromo-methyl exchange rules in these compounds (Swamy et al., 2020).
• Fungicidal Activity :
  • Compounds related to 2-Chloro-4-(4-fluorophenyl)thiazole have been synthesized and evaluated for their fungicidal activity. These compounds showed promising activity against plant pathogens like Colletotrichum gossypii (Shen De-long, 2010).
• Antioxidant Activity :
  • Thiazolidin-4-one derivatives, prepared using 4-Fluorobenzaldehyde (structurally similar to 2-Chloro-4-(4-fluorophenyl)thiazole), showed promising antioxidant activity. This highlights the potential of such derivatives in pharmaceutical applications (El Nezhawy et al., 2009).
• Structural Characterization :
  • Isostructural thiazoles, including derivatives of 2-Chloro-4-(4-fluorophenyl)thiazole, were synthesized and characterized. These studies provided insights into molecular conformation and crystal structures, important for understanding the properties of these compounds (Kariuki et al., 2021).
• Corrosion Inhibition :
  • Certain thiazole derivatives, including those structurally related to 2-Chloro-4-(4-fluorophenyl)thiazole, have been evaluated as corrosion inhibitors for mild steel in acidic environments. Their effectiveness in protecting metals underlines their industrial application potential (Gong et al., 2019).

Safety And Hazards

The compound is labeled with the GHS07 pictogram and has the signal word “Warning”. Hazard statements include H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Precautionary statements include P261 (Avoid breathing dust/fume/gas/mist/vapors/spray), P280 (Wear protective gloves/protective clothing/eye protection/face protection), P301+P312 (IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell), P302+P352 (IF ON SKIN: Wash with plenty of soap and water), and P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing).

Future Directions

While specific future directions for 2-Chloro-4-(4-fluorophenyl)thiazole-5-carbonitrile are not available in the retrieved data, thiazole derivatives are a topic of ongoing research due to their potential biological activities. Further studies could explore the synthesis, properties, and potential applications of this compound in greater detail.

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