163733-96-8 | 3,4,5-Trifluoroaniline

CAS:163733-96-8 | 3,4,5-Trifluoroaniline,Description

Synthesis Analysis

Molecular Structure Analysis

The molecular structure of fluoroaniline derivatives, including 3,4,5-Trifluoroaniline , has been extensively studied using various spectroscopic methods. Studies on similar compounds like 3,5-Difluoroaniline have shown detailed analyses of their geometrical and electronic structures, providing insight into the effects of fluorine substituents on the molecule's properties (S. Pathak et al., 2015).

Chemical Reactions and Properties

The presence of trifluoromethyl groups significantly affects the chemical reactivity of aniline derivatives. For instance, the synthesis of trifluoromethylated analogues of 4,5‐Dihydroorotic Acid showcases the reactivity of such compounds in creating biologically relevant molecules (V. Sukach et al., 2015).

Scientific Research Applications

• Organic Synthesis :
  • Summary of the Application : 3,4,5-Trifluoroaniline is often used as an electron-deficient aniline for substrate scope study in organic synthesis. It can be used to synthesize (E)-1-(2-nitrophenyl)-2-(3,4,5-trifluorophenyl)diazene.
• Thermophysical Property Data Analysis :
  • Summary of the Application : 3,4,5-Trifluoroaniline has been used in the study of thermophysical property data. This involves the analysis of properties such as boiling point, critical temperature and pressure, density, and heat capacity.
  • Methods of Application : These studies typically involve the use of software packages for dynamic data analysis, such as the NIST ThermoData Engine.
  • Results or Outcomes : The outcomes of these studies include a better understanding of the thermophysical properties of 3,4,5-Trifluoroaniline, which can be useful in various scientific and industrial applications.
• Functionalization of Single Wall Carbon Nanotubes (SWCNTs) :
  • Summary of the Application : 3,4,5-Trifluoroaniline can be used to functionalize single wall carbon nanotubes (SWCNTs), generating distinct fluorescence bands at longer wavelengths from the emission of SWCNTs.
  • Methods of Application : The functionalization of SWCNTs is performed in one pot with 3,4,5-trifluoroaniline, SWCNTs, sodium nitrite and chlorosulfonic acid.
  • Results or Outcomes : The functionalized SWCNTs can produce organic color centers, which may have potential applications in various fields such as sensors, optoelectronics, and nanotechnology.
• Synthesis of Hepatitis B Virus Capsid Assembly Modulator :
  • Summary of the Application : A capsid assembly modulator that inhibits the replication of hepatitis B virus can be synthesized from 3,4,5-trifluoroaniline.
• Development of Quasi-2D Perovskite Film for OLEDs :
  • Summary of the Application : A quasi-2D perovskite film consisting of lead bromide and 3,4,5-trifluoroaniline displays the maximum luminance of 1.2 × 10^3 cd/m^2 and current efficiency up to 0.3 cd/A.
• Cytochrome P450 2E1/2A6-Selective Inhibition :
  • Summary of the Application : 3,4,5-Trifluoroaniline and other halogenated anilines have been used to study Cytochrome P450 2E1/2A6-selective inhibition on metabolic activation of dimethylnitrosamine in human liver microsomes.
  • Results or Outcomes : The outcomes of these studies would be a better understanding of the metabolic activation of dimethylnitrosamine in human liver microsomes, which can be useful in various scientific and medical applications.
• Thermophysical Property Data Analysis :
  • Summary of the Application : 3,4,5-Trifluoroaniline has been used in the study of thermophysical property data. This involves the analysis of properties such as boiling point, critical temperature and pressure, density, and heat capacity.
  • Methods of Application : These studies typically involve the use of software packages for dynamic data analysis, such as the NIST ThermoData Engine.
  • Results or Outcomes : The outcomes of these studies include a better understanding of the thermophysical properties of 3,4,5-Trifluoroaniline, which can be useful in various scientific and industrial applications.

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