1642298-59-6 | 3-(fluoromethyl)azetidine hydrochloride

CAS:1642298-59-6 | 3-(fluoromethyl)azetidine hydrochloride,Description

3-(Fluoromethyl)azetidine hydrochloride is a chemical compound with the CAS Number: 1642298-59-6. It has a molecular weight of 125.57.

Molecular Structure Analysis

The molecular formula of 3-(Fluoromethyl)azetidine hydrochloride is CHFN. It has an average mass of 89.111 Da and a monoisotopic mass of 89.064079 Da.

Physical And Chemical Properties Analysis

3-(Fluoromethyl)azetidine hydrochloride has a density of 1.0±0.1 g/cm^3. It has a boiling point of 93.9±5.0 °C at 760 mmHg. The vapour pressure is 48.5±0.2 mmHg at 25°C. The enthalpy of vaporization is 33.4±3.0 kJ/mol. The flash point is 10.6±17.6 °C. The index of refraction is 1.387. The molar refractivity is 22.0±0.3 cm^3. It has 1 H bond acceptor and 1 H bond donor. It has 1 freely rotating bond. The polar surface area is 12 Å^2. The polarizability is 8.7±0.5 10^-24 cm^3. The surface tension is 23.9±3.0 dyne/cm. The molar volume is 93.5±3.0 cm^3.

Scientific Research Applications

1. Imaging and Diagnostics

A significant application of azetidine derivatives, including compounds related to 3-(Fluoromethyl)azetidine, is in imaging, particularly positron emission tomography (PET). For instance, the azetidine derivative A-85380 and its fluoro derivative F-A-85380 have been explored for their binding properties with nicotinic acetylcholine receptors (nAChRs), showing promising properties for PET imaging of central nAChRs (Doll et al., 1999).

2. Synthesis and Drug Development

Azetidine derivatives have been employed in the synthesis of novel drugs. For example, azetidines derived from phenyl urea derivatives have been synthesized and characterized, displaying potential antioxidant effects (Nagavolu et al., 2017). Similarly, quinolone antibiotics utilizing azetidine derivatives obtained from 1-azabicyclo[1.1.0]butane have been synthesized, some showing greater antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (Ikee et al., 2008).

3. Therapeutic Applications

Azetidine derivatives have been explored for their therapeutic potentials. For instance, azetidine-based inhibitors of dipeptidyl peptidase IV (DPP IV) have shown submicromolar potency, indicating potential applications in the treatment of type 2 diabetes and other disorders (Ferraris et al., 2007).

4. Research in Biochemistry and Plant Physiology

Azetidine compounds have been used to study the relationship between protein synthesis and ion transport in plants. For example, the effect of azetidine 2-carboxylic acid on ion uptake and release in barley roots provides insights into the mechanisms of ion transport in plants (Pitman et al., 1977).

5. Chemical Process Development and Safety

The development of safe and efficient synthetic processes for azetidine derivatives is another area of research. For instance, a study describes the scalable process for the production of a highly energetic bromoacetylene building block, highlighting the importance of safety investigations in chemical process development (Kohler et al., 2018).

Safety And Hazards

The safety information for 3-(Fluoromethyl)azetidine hydrochloride includes a GHS07 pictogram. The signal word is "Warning". Hazard statements include H315 and H319. Precautionary statements include P264, P280, P302, P305, P313, P332, P337, P338, P351, P352, and P362.

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